{"count":565,"next":null,"previous":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/grants_received/?limit=100&offset=415","results":[{"grant_id":"360G-Wellcome-226306_A_22_Z","data":{"id":"360G-Wellcome-226306_A_22_Z","title":"The CIDACS Climate and Environmental Platform (CIDACS-Clima): A data resource to study climate and health  ","Region":"London","currency":"GBP","awardDate":"2022-09-30T00:00:00+00:00","Internal ID":"226306/A/22/Z","description":"As a large middle-income country with extraordinary geographic diversity and stark social inequalities, Brazil offers a unique living laboratory for identifying specific factors that may modify and mediate the impacts of climate change on health. To generate new knowledge on the links between climate and health that is currently not available from existing dissipated and unlinked resources and to inform mitigation and adaptation responses, this proposal seeks to develop a new CIDACS Climate and Environmental Platform. Our primary aim is to integrate geo-referenced climatic data (e.g., hydrometeorological and remote sensing satellite-derived indicators) from Brazil in an accessible platform that will be interoperable with the existing nationwide health and socioeconomic data linked in the 100 Million Brazilian Cohort (N=131,697,800 low-income individuals, 2001-2018) and the CIDACS Birth Cohort (N=28,631,390 maternal-child dyads, 2001-2018). To achieve this aim, we are requesting resources to: (i) strengthen CIDACS’ computational infrastructure including high-performance computing clusters, (ii) bolster CIDACS’ technical capacity related to data linkage and interoperability, machine learning, and bias assessment, (iii) develop the CIDACS Climate and Environmental Platform data resource, (iv) conduct hypothesis-driven proof-of- concept studies to demonstrate the platform’s utility and validity, and (v) expand CIDACS’ public interface and governance mechanisms to facilitate ethical data access.","plannedDates":[{"endDate":"2028-10-31T00:00:00+00:00","startDate":"2023-11-01T00:00:00+00:00"}],"amountAwarded":419213,"Financial Year":"2021/22","Lead Applicant":"Prof Elizabeth Brickley","grantProgramme":[{"title":"Discretionary Award"}],"Applicant Surname":"Brickley","Approval Committee":"Internal Decision Panel","Other Applicant(s)":"Dr Julia Moreira Pescarini, Dr Maria Yury Travassos Ichihara, Dr Gervasio Ferreira Santos, Prof Roberto F S Andrade, Dr Enny da Paixao Cruz, Prof Manoel Barral Netto, Prof Liam Smeeth, Dr Gustavo Correa Matta","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"Yes","Total amount including partnership funding":419213},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-226350_Z_22_Z","data":{"id":"360G-Wellcome-226350_Z_22_Z","title":"What drives Plasmodium vivax transmission in incident or relapsing infections (DRIVAX)?  ","Region":"London","currency":"GBP","awardDate":"2022-11-24T00:00:00+00:00","Sponsor(s)":"Prof Chris Drakeley, Dr Endalamaw Belachew, Prof Richard Price, Dr Michael White","Internal ID":"226350/Z/22/Z","description":"The hypnozoite stage of Plasmodium vivax malaria causes relapsing infections, responsible for a high proportion of clinical and >70% of recurrent infections. Relapses may also be critical for the onward malaria transmission to mosquitoes and undermine malaria elimination efforts. However, the precise contribution of relapses has yet to be quantified. I hypothesize that the rapid production of P. vivax gametocytes renders many relapsing infections transmissible, but that acquisition of specific immunity will reduce transmission efficiency. My proposal aims to examine the infectivity of relapsing infections compared to incident infections and identify the key host and parasite factors that influence transmission. I will compare the kinetics of parasite and gametocyte densities in the incident and recurrent infections and integrate these data with a detailed assessment of transmissibility to mosquitoes in relation to the transmission-modulating effect of antibody responses to gametocyte antigens. I will deploy advanced genotyping tools to determine the genetic associations between the incident and recurrent infections in humans and subsequent mosquito infections. My proposal will provide the most comprehensive assessment to date of parasite kinetics and transmissibility in natural P. vivax infections, quantifying the importance of relapse infections to the infectious reservoir and informing malaria control and elimination strategies.","plannedDates":[{"endDate":"2028-04-30T00:00:00+00:00","startDate":"2023-05-01T00:00:00+00:00"}],"amountAwarded":807024,"Financial Year":"2022/23","Lead Applicant":"Dr Fitsum Girma Tadesse","grantProgramme":[{"title":"Early-Career Award"}],"Applicant Surname":"Tadesse","Approval Committee":"ECA Interview Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"Yes","Total amount including partnership funding":807024},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-226432_Z_22_Z","data":{"id":"360G-Wellcome-226432_Z_22_Z","title":"AMRnet  ","Region":"London","currency":"GBP","awardDate":"2022-09-30T00:00:00+00:00","Internal ID":"226432/Z/22/Z","description":"Antimicrobial resistance (AMR) is a leading global health priority, contributing to an estimated 5 million deaths in 2019. It is a complex problem, with the potential to compromise the overall safety of healthcare delivery, from surgery to chemotherapy. AMR surveillance is described by the World Health Organisation as an essential tool to inform policies and infection prevention & control responses, however for many pathogens diagnostics and surveillance are not routinely performed. There is untapped potential for pathogen genomic data, derived from research and public health sectors, to fill gaps in AMR surveillance and inform policies and responses to the global AMR crisis. However whilst there is already an established culture of pathogen sequence data sharing, these data are essentially invisible to policymakers. This project aims to address this by making high-quality, robust and reliable genome-derived AMR surveillance data accessible to as wide an audience as possible, via a free and open-source online dashboard called AMRnet. This will be achieved by developing integrated solutions to multiple related challenges including data flow, organism-specific interpretive frameworks, and simple visualisations for complex data. Community engagement will be central to the project, to ensure its growth and sustainability.","plannedDates":[{"endDate":"2027-01-08T00:00:00+00:00","startDate":"2023-01-09T00:00:00+00:00"}],"amountAwarded":983969,"Financial Year":"2021/22","Lead Applicant":"Prof Kathryn Elizabeth Holt","grantProgramme":[{"title":"Discretionary Award"}],"Applicant Surname":"Holt","Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":983969},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-226899_Z_23_Z","data":{"id":"360G-Wellcome-226899_Z_23_Z","title":"Open Access Award 2022/23  ","Region":"London","currency":"GBP","awardDate":"2023-09-30T00:00:00+00:00","Internal ID":"226899/Z/23/Z","description":"No description available","plannedDates":[{"endDate":"2023-12-31T00:00:00+00:00","startDate":"2022-10-01T00:00:00+00:00"}],"amountAwarded":210712,"Financial Year":"2022/23","Lead Applicant":"Prof Liam Smeeth","grantProgramme":[{"title":"Open Access Award"}],"Applicant Surname":"Smeeth","Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":210712},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-227053_Z_23_Z","data":{"id":"360G-Wellcome-227053_Z_23_Z","title":"Genetic risk for major depressive disorder among three ethnically diverse African cohorts  ","Region":"London","currency":"GBP","awardDate":"2023-03-28T00:00:00+00:00","Sponsor(s)":"Prof Eugene Kinyanda, Prof Cathryn Lewis","Internal ID":"227053/Z/23/Z","description":"Whereas we are aware of the roles genetics play in the development of major depressive disorder (MDD) (mainly from research among Caucasian populations), there remains a dearth in literature about specific genes affecting susceptibility among continental Africans. Moreover, African ancestry individuals harbour marked genetic diversity compared to persons from the rest of the world. To address this gap, I propose to investigate the genetic risk factors for MDD among continental Africans by (i) performing a genome-wide association study of MDD among pooled data from three ethnically diverse African cohorts (GPC, NeuroGAP and DepGenAfrica cohorts, n~23,776), (ii) replicate findings in an African/African-admixed PGC Cohort (n=198,497), (iii) meta-analyse findings from these combined cohorts (n~23,776 + n=198,497) and (iv) combine these results with the rest of the MDD PGC dataset (n~23,776, n=198,497 and n=1,622,192) in a final meta-analysis. Transferability of variants and MDD polygenic risk scores between the continental African cohort and PGC cohorts will also be determined. In the continental Africans dataset, causal relations for MDD will be investigated and a machine learning model for prediction of MDD will be built. This study has potential to identify mechanistic pathways and ultimately lead to development of new molecules or drug targets for MDD.","plannedDates":[{"endDate":"2028-05-31T00:00:00+00:00","startDate":"2023-06-01T00:00:00+00:00"}],"amountAwarded":535941,"Financial Year":"2022/23","Lead Applicant":"Dr Allan Kalungi","grantProgramme":[{"title":"Early-Career Award"}],"Applicant Surname":"Kalungi","Approval Committee":"ECA Interview Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"Yes","Total amount including partnership funding":535941},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-227165_Z_23_Z","data":{"id":"360G-Wellcome-227165_Z_23_Z","title":"Pathfinder 2: accelerating climate action for health  ","Region":"London","currency":"GBP","awardDate":"2023-09-30T00:00:00+00:00","Internal ID":"227165/Z/23/Z","description":"Pathfinder 2 aims to catalyse and support successful action on climate mitigation with a focus on measured co-benefits for health. The first phase of the Pathfinder Initiative synthesised evidence on actions with the largest potential co-benefits, including energy, transport and agriculture/ food sectors. The second phase of the project will focus on three key areas where progress is needed: evidence for action, monitoring and evaluating progress; and capacity strengthening. First, machine learning techniques will be used to bring together relevant evidence and make it accessible to actors using a living evidence map. Second, a Coalition of research, enabling and implementing partners will be set up to galvanise the implementation of informed actions and their evaluation. Third, a community of practice will be brought together for sharing of knowledge and tools. The key goals of the project are to identify and deliver context-specific evidence on health co- benefits, and to strengthen global capacity to implement and evaluate climate mitigation actions that will promote human health. Building on the successful Lancet Commission brought together for the first phase of Pathfinder, this work will be guided by a panel of experts from across disciplines and global regions, with major multilateral organisations represented.","plannedDates":[{"endDate":"2026-09-30T00:00:00+00:00","startDate":"2023-09-01T00:00:00+00:00"}],"amountAwarded":3568090,"Financial Year":"2022/23","Lead Applicant":"Prof Andrew Haines","grantProgramme":[{"title":"Discretionary Award"}],"Applicant Surname":"Haines","Approval Committee":"Internal Decision Panel","Other Applicant(s)":"Dr Sarah Whitmee, Prof Morgan Edwards, Dr Lorna Benton, Dr Elizabeth Wambui Kimani-Murage, Prof Jonathan A Patz, Prof Rosemary Green, Dr Max Callaghan, Dr Jan C. Minx, Dr Bernard Onyango","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"Yes","Total amount including partnership funding":3568090},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-227176_Z_23_Z","data":{"id":"360G-Wellcome-227176_Z_23_Z","title":"Evaluating pathophysiological mechanisms of acute and chronic heat stress on maternal and fetal health  ","Region":"London","currency":"GBP","awardDate":"2023-02-01T00:00:00+00:00","Internal ID":"227176/Z/23/Z","description":"Maternal exposure to acute and chronic heat stress predicts multiple adverse birth outcomes with long-term impacts, but pathophysiological pathways remain undefined. West Africa is particularly affected by extreme heat. This project seeks to describe the physiological, biochemical and structural changes in pregnancy due to heat stress. Five integrated work packages are proposed. WP1 will synthesise global evidence for human and non-human primate maternal responses to heat exposure in pregnancy. WP2a will employ environmental chamber studies (FAME Lab Athens) to determine heat stress thresholds for acute maternal, fetal, and materno-placental physiological stress accompanied by a simplified heat-chamber protocol in The Gambia (WP2b). WP3 will be a longitudinal cohort study of 762 pregnant women conducted across 3 heat gradient environments in The Gambia. Outcome measures include maternal physiology & sleep quality (wearable device), materno-placental interface (placental blood flow), pregnancy outcomes and newborn neurobehaviour. WP4 will use placenta samples collected in WP3 to assess the impact of heat stress on placental structure, function and molecular changes. WP5 will use Gambian community workshops to co-design adaptation strategies building on evidence from WPs1-4. This project will build local research capacity, foster international collaborative links and engage communities, key stakeholders and policy makers.","plannedDates":[{"endDate":"2028-05-31T00:00:00+00:00","startDate":"2023-06-01T00:00:00+00:00"}],"amountAwarded":2049397,"Financial Year":"2022/23","Lead Applicant":"Dr Ana Bonell","grantProgramme":[{"title":"Directed Call"}],"Applicant Surname":"Bonell","Approval Committee":"Heat Physiology Call Advisory Committee","Other Applicant(s)":"Prof Andrew M Prentice, Dr Leonidas G. Ioannou, Prof Amanda N Sferruzzi-Perri, Prof Andreas D Flouris, Dr Bubacarr Bah","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"Yes","Total amount including partnership funding":2049397},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-227510_Z_23_Z","data":{"id":"360G-Wellcome-227510_Z_23_Z","title":"Tuberculosis and the heart: determining the burden and natural history of cardiac pathology at TB diagnosis among HIV-infected and uninfected individuals in Zambia.  ","Region":"London","currency":"GBP","awardDate":"2023-09-30T00:00:00+00:00","Internal ID":"227510/Z/23/Z","description":"Recent studies suggest heart disease occurs more frequently than previously acknowledged in patients with tuberculosis (TB), but biological processes underlying this relationship have not been consistently studied in Sub-Saharan Africa (SSA), where TB remains an urgent health priority and is often complicated by Human Immunodeficiency Virus (HIV) co-infection. In this fellowship, we will systematically review existing evidence describing the pattern and frequency of heart disease that occurs among patients with TB in SSA. Next, in a study in Zambia, we will recruit participants with TB with and without HIV to quantify and compare the frequency and spectrum of heart disease. Participants will undergo detailed cardiac assessments using standard and portable echocardiography – a tool used to detect damage to cardiac structures and assess heart function – and blood sampling to measure markers of cardiac disease. In those with evidence of heart disease at recruitment, we will repeat assessments at six months to describe how heart disease evolves over time. Together, these studies will address important gaps in understanding the relationship between TB and heart disease, how this differs HIV co-infected patients, and evaluate novel tools to improve detection of heart disease in routine TB and HIV care in SSA.","plannedDates":[{"endDate":"2025-12-31T00:00:00+00:00","startDate":"2022-09-01T00:00:00+00:00"}],"amountAwarded":0,"Financial Year":"2022/23","Lead Applicant":"Dr Marcello Scopazzini","grantProgramme":[{"title":"PhD Studentship for Health Professionals"}],"Applicant Surname":"Scopazzini","Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":0},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-227511_Z_23_Z","data":{"id":"360G-Wellcome-227511_Z_23_Z","title":"Co-design and process evaluation of integrated sexual and reproductive health services offered to people accessing HIV care in Zimbabwe with specific focus on health providers  ","Region":"London","currency":"GBP","awardDate":"2023-09-30T00:00:00+00:00","Internal ID":"227511/Z/23/Z","description":"Sexual and reproductive health (SRH) and Human Immunodeficiency Virus (HIV) are important issues in global health. HIV programmes are often delivered in silosTime with progress integrating SRH and HIV being particularly slow. There is evidence of some successes and challenges of integration including staffing shortages and financial constraints in low-resource settings, however, there is little evidence connecting health provider challenges implementing integrated services with their personal and professional experiences. My research aims to inform how to co-design HIV and SRH services with health providers for people accessing HIV care in Zimbabwe. The study will be conducted in a peri-urban public clinic where approximately 1,100 people attend for HIV care. My study will consist of three phases. The first will be gaining an in-depth understanding of health provider's experience of delivering current HIV services using ethnographic methods. The second is to co-design an integrated of SRH and HIV service delivery model within existing HIV services and the third is to conduct a mixed-methods process evaluation to understand the acceptability, feasibility, uptake and yield of integrated HIV and SRH services in clinic-based settings. My study will improve understanding on the role of combined care in improving much needed HIV/SRH services for PLHIV.","plannedDates":[{"endDate":"2026-11-27T00:00:00+00:00","startDate":"2022-09-28T00:00:00+00:00"}],"amountAwarded":0,"Financial Year":"2022/23","Lead Applicant":"Miss Rumbidzai Anne Gumbie","grantProgramme":[{"title":"PhD Studentship for Health Professionals"}],"Applicant Surname":"Gumbie","Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":0},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-227647_Z_23_Z","data":{"id":"360G-Wellcome-227647_Z_23_Z","title":"Significance of Hypertension in Early Adulthood Research (SHEAR)  ","Region":"London","currency":"GBP","awardDate":"2023-07-31T00:00:00+00:00","Sponsor(s)":"Dr Shungu Munyati, Prof Rashida Ferrand","Internal ID":"227647/Z/23/Z","description":"Essential hypertension is the leading preventable cause of cardiovascular disease and death, and has traditionally been associated with ageing. However, high prevalence of elevated blood pressure (BP) has increasingly been reported among youth in sub-Saharan Africa (SSA), posing challenges for clinical management. My fellowship will address critical evidence gaps on BP among youth in SSA. I will examine: \\- population prevalence of hypertension in urban Zimbabwean youth and the agreement between routine brachial BP and the potentially more clinically-predictive central aortic BP. \\- the population prevalence of early vascular ageing (EVA) and hypertension-mediated organ damage (HMOD), and the BP profiles at which they occur. \\- the context- specific aetiological factors associated with elevated blood pressure, EVA and HMOD. I will conduct a detailed cross-sectional study of 650 individuals, randomly selected from a large population-based health survey of youth conducted in Zimbabwe in 2022 (N~17,000; 18-24y). This will provide population estimates of brachial and central hypertension, EVA and HMOD. I will examine risk factors and measure novel biomarkers (including immune markers, telomere length analyses and metabolomics) to conduct state-of-the-art causal inference studies. The fellowship will have clinically important implications for hypertension screening, prevention and treatment guidelines for youth in SSA.","plannedDates":[{"endDate":"2029-04-30T00:00:00+00:00","startDate":"2024-05-01T00:00:00+00:00"}],"amountAwarded":1185342,"Financial Year":"2022/23","Lead Applicant":"Dr Kalpana N Sabapathy","grantProgramme":[{"title":"Early-Career Award"}],"Applicant Surname":"Sabapathy","Approval Committee":"ECA Interview Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"Yes","Total amount including partnership funding":1185342},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-228270_Z_23_Z","data":{"id":"360G-Wellcome-228270_Z_23_Z","title":"Developing VizImmune: a platform for visualising in-host immune kinetics  ","Region":"London","currency":"GBP","awardDate":"2023-09-30T00:00:00+00:00","Internal ID":"228270/Z/23/Z","description":"With the Wellcome Ideathon grant, we will develop VizImmune, an open-source platform to leverage immunological biomarker data for infectious diseases and immunology research for academic researchers, including modellers, statisticians, and experimental research scientists. VizImmune will fill in key gaps in the utilisation of immunological biomarker data, address challenges in data aggregation and standardisation, and provide a platform with integrated visualisation and statistical tools to help explore potential trends in complex datasets. Crucial in its development is a collaboration with global lab research groups that collect and analyse immunological biomarker data. Co-development with these groups, the targeted end-user of VizImmune, from the outset of its development, will ensure the platform remains accessible, maximising its impact and making progress towards establishing itself as a gold standard for analysis of immune biomarker data. A fully developed platform with integrated visualisation and statistical analysis could increase accessibility of existing open-source immunological datasets, deepen understanding of immunological responses to vaccination and infection and potentially accelerate vaccine development by identifying correlates of protection for a suite of infectious pathogens. Vizimmune offers an integrated solution with comprehensive insights into immunological biomarker data, presenting a promising contribution to the field.","plannedDates":[{"endDate":"2025-04-14T00:00:00+00:00","startDate":"2024-04-15T00:00:00+00:00"}],"amountAwarded":97089,"Financial Year":"2022/23","Lead Applicant":"Dr David Hodgson","grantProgramme":[{"title":"Discretionary Award"}],"Applicant Surname":"Hodgson","Approval Committee":"Wellcome Data Science Ideathon","Other Applicant(s)":"Dr Gavin Kelly, Prof Elizabeth J Williamson, Dr Timothy William Russell","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":97089},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-301191_Z_23_Z","data":{"id":"360G-Wellcome-301191_Z_23_Z","title":"Investigating innovative approaches to identify lean individuals at risk of type 2 diabetes in SSA.  ","Region":"London","currency":"GBP","awardDate":"2023-10-19T00:00:00+00:00","Sponsor(s)":"Prof Moffat Nyirenda","Internal ID":"301191/Z/23/Z","description":"Type 2 diabetes (T2D) poses a major threat in sub-Saharan Africa (SSA); 24 million people are thought to have T2D, but this is projected to increase by 129% by 2045 (the greatest increase of all regions). However, most people living with T2D are undiagnosed. Established risk factors for T2D include family history, old age and obesity, and these are widely used in screening tools. Increasing evidence suggests that in Africa T2D occurs at relatively young age and in lean individuals who would be missed by these screening approaches. For example, in Uganda, nearly 60% of those identified to have diabetes through community screening are lean (<25kg/m2). This may explain, at least in part, why most people with T2D in the region remain undiagnosed, and those who are diagnosed present late with established complications of this condition. This project will capitalize on a large and rigorous ongoing community survey of diabetes and other existing datasets to examine and validate which simple clinical features and biomarkers can identify risk of T2D in lean individuals in in Africa. The end result will be development of clinical tools needed to guide risk prediction and increase T2D detection in lean individuals in SSA.","plannedDates":[{"endDate":"2029-01-31T00:00:00+00:00","startDate":"2024-02-01T00:00:00+00:00"}],"amountAwarded":711852,"Financial Year":"2023/24","Lead Applicant":"Dr Anxious Jackson Niwaha","grantProgramme":[{"title":"Early-Career Award"}],"Applicant Surname":"Niwaha","Approval Committee":"ECA Interview Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"Yes","Total amount including partnership funding":711852},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-305644_Z_23_Z","data":{"id":"360G-Wellcome-305644_Z_23_Z","title":"Evaluating the impacts of climate and environmental stressors on migration and migrant health in Brazil  ","Region":"London","currency":"GBP","awardDate":"2024-04-30T00:00:00+00:00","Sponsor(s)":"Prof Elizabeth Allen","Internal ID":"305644/Z/23/Z","description":"Climate and environmental change are key drivers of human displacement and migration, which may compromise the physical and mental health of affected populations. The deleterious impacts of exposure to climate and environmental stressors may be mitigated by improving social and health safety nets to prevent displacement or to support migrants. However, current evidence on the health implications of migration, especially in Low- and Middle-income Countries, remains scarce and imprecise. This proposal will capitalize on Fiocruz’s CIDACS Climate and Environmental Platform, a unique and interdisciplinary data resource linking longitudinal and geocoded environmental, sociodemographic and health data on over 130 million people over 18 years in Brazil. In this fellowship, I aim to discover how climate and environmental stressors shape internal migration in Brazil and impact the health of both internal and international migrants. Specifically, I will quantify how specific climate and environmental stressors (e.g., heatwaves, floods) (i)drive migration, (ii)contribute to communicable and non- communicable diseases, adverse birth outcomes, and mortality across subgroups (e.g., minoritized individuals), and (iii)can be mitigated by social protection programmes. Finally, I will simulate how social protection can mitigate the harmful effects of future climate and environmental events to inform actions and migrant-centered policies to improve population’s resilience.","plannedDates":[{"endDate":"2032-10-31T00:00:00+00:00","startDate":"2024-11-01T00:00:00+00:00"}],"amountAwarded":2048855,"Financial Year":"2023/24","Lead Applicant":"Dr Julia Moreira Pescarini","grantProgramme":[{"title":"Career Development Award"}],"Applicant Surname":"Pescarini","Approval Committee":"CDA Interview Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":2048855},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-306920_Z_23_Z","data":{"id":"360G-Wellcome-306920_Z_23_Z","title":"Viral genomic surveillance in the era of million-sequence trees  ","Region":"London","currency":"GBP","awardDate":"2024-04-30T00:00:00+00:00","Sponsor(s)":"Prof Taane Clark","Internal ID":"306920/Z/23/Z","description":"Pathogen genomes begin to reveal insights into spread and evolution when assembled into a phylogenetic tree. The SARS-CoV-2 pandemic has led to a new scale of viral genomic data that has challenged traditional computational tools for analysing and exploring trees, but which when harnessed offers striking new avenues for understanding pathogen biology: these virus sequences are the data from a natural experiment that reveal the fitness of tens of thousands of virus genotypes, and provide insight into the forces shaping viral evolution. In this project, we will expand a toolkit I have developed for large-scale phylogenetics in this new era of sequencing, and apply it to a range of viral pathogens. We will build regularly updated large trees for these species, both serving the research community and providing a platform for our own work. We will use deep-learning to transform these large-scale trees into maps of viral fitness landscapes, including modelling epistasis. Additionally we will use the trees to monitor the forces shaping virual evolution, including the impact of external factors like mutagenic drugs and host shifts. This will enable systematic surveillance of viral evolution, offering early warnings of significant changes that could affect global public health.","plannedDates":[{"endDate":"2032-08-04T00:00:00+00:00","startDate":"2024-08-05T00:00:00+00:00"}],"amountAwarded":2084119,"Financial Year":"2023/24","Lead Applicant":"Theo Sanderson","grantProgramme":[{"title":"Career Development Award"}],"Applicant Surname":"Sanderson","Approval Committee":"CDA Interview Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":2084119},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-307047_Z_23_Z","data":{"id":"360G-Wellcome-307047_Z_23_Z","title":"Multimorbidity and Learning Health Systems: Optimising Data-to-Action (OptiMuL)  ","Region":"London","currency":"GBP","awardDate":"2024-04-30T00:00:00+00:00","Sponsor(s)":"Prof Kara Hanson","Internal ID":"307047/Z/23/Z","description":"Multimorbidity, or the co-occurrence of two-or-more diseases in one person, is among the most significant emerging challenges for health systems globally. Multimorbidity indexes the breakdown of health systems organised around single diseases, which in many African nations translates into siloed organisation of care, fuelled by ‘vertical’ single-disease-centred programming. Key to responding to multimorbidity and its associated complexity – indeed, to many complex health system challenges – is capacity to generate and use robust, locally-relevant knowledge. ‘Learning health systems’ is a novel framework developed within health policy and systems research (HPSR) that elevates the importance of investing in practical learning across entrenched hierarchies and siloes of knowledge. Taking forward the synergies between multimorbidity and learning health systems conversations, OptiMuL is a cross-disciplinary, co-productive research programme that brings together academics, policymakers, and practitioners in Zimbabwe through a pilot multimorbidity learning hub to enhance understandings and system capabilities for addressing multimorbidity in Zimbabwe. Collapsing ‘evidencing’ and ‘intervening’ through the framework of learning, OptiMuL will simultaneously evidence and contribute towards a multimorbidity-responsive health system in Zimbabwe. In doing so, it provides insights into how knowledge and practice might synergise within a genuinely ‘person-centred’ system and the processes through which such systems can be realized.","plannedDates":[{"endDate":"2029-08-31T00:00:00+00:00","startDate":"2024-09-01T00:00:00+00:00"}],"amountAwarded":1009238,"Financial Year":"2023/24","Lead Applicant":"Dr Justin Dixon","grantProgramme":[{"title":"Career Development Award"}],"Applicant Surname":"Dixon","Approval Committee":"CDA Interview Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":1009238},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-307232_Z_23_Z","data":{"id":"360G-Wellcome-307232_Z_23_Z","title":"Disability Inclusive Youth (DIY) research: an innovative and co-creative programme to improve inclusion of children and youth with disabilities in health research in East Africa  ","Region":"London","currency":"GBP","awardDate":"2024-04-30T00:00:00+00:00","Sponsor(s)":"Prof Elizabeth Allen","Internal ID":"307232/Z/23/Z","description":"Young people with disabilities are rarely included in research, yet 75% of the East African population is under 30 years old and an estimated 15% have a disability. Without including young persons with disabilities in designing and implementing health research, we will not achieve global development goals. This programme will forge a novel participatory approach to include children and youth with disabilities in health research in East Africa. I will foster and expand my network and build the research capacity of 12 youth with disabilities in Uganda, Kenya and Rwanda and partner universities to explore the barriers and facilitators to disability inclusive health research. The youth researchers will interview leading health researchers, key health stakeholders, government and research organisations, health service providers and children and youth with disabilities. Together with the youth I will establish recommendations to make health research more inclusive of children and youth with disabilities. I will establish myself as a regional research lead on innovative disability inclusive health research. I will encourage and facilitate youth led knowledge sharing and awareness raising in partnership with disabled persons organizations and contribute to disability inclusive health care and the creation of a decolonized, equitable, diverse, and inclusive research community.","plannedDates":[{"endDate":"2029-08-31T00:00:00+00:00","startDate":"2024-09-01T00:00:00+00:00"}],"amountAwarded":1453870,"Financial Year":"2023/24","Lead Applicant":"Dr Femke Bannink Mbazzi","grantProgramme":[{"title":"Career Development Award"}],"Applicant Surname":"Bannink Mbazzi","Approval Committee":"CDA Interview Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"Yes","Total amount including partnership funding":1453870},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-307859_Z_23_Z","data":{"id":"360G-Wellcome-307859_Z_23_Z","title":"Inequalities in Lifespans and Life Lost due to COVID-19: Pioneering Demographic Science and Analysis  ","Region":"London","currency":"GBP","awardDate":"2024-04-30T00:00:00+00:00","Sponsor(s)":"Prof Suneetha Kadiyala","Internal ID":"307859/Z/23/Z","description":"The COVID-19 pandemic triggered an unprecedented rise in mortality around the world. Our knowledge of the impacts of the pandemic on population health is limited and the medium, and long term, consequences are unknown. Life expectancy is the most used metric of population health and longevity. However, life expectancy, as an average indicator, masks variation in length of life, and thus the inherent variation in patterns of mortality. This variation is a fundamental type of inequality that expresses how diverse ages at death are at the population level. This project addresses three major objectives to produce fundamentally new knowledge of the mechanisms that underpin recent mortality trends: 1) To complement all-cause mortality analysis with multiple causes of death to uncover the indirect pathways through which the pandemic has affected mortality; 2) develop and apply demographic methods to quantify how different causes of death affect patterns of life years lost by sex; and 3) analyse the effects of the COVID-19 pandemic on lifespan inequality. At the intersection of demography with multiple disciplines, including epidemiology, data science, and public health, this project focuses on pressing issues about the toll of the COVID-19 pandemic on population health, and challenges current narratives on longevity.","plannedDates":[{"endDate":"2030-02-28T00:00:00+00:00","startDate":"2025-03-01T00:00:00+00:00"}],"amountAwarded":1328211,"Financial Year":"2023/24","Lead Applicant":"Dr José Manuel Aburto","grantProgramme":[{"title":"Career Development Award"}],"Applicant Surname":"Aburto","Approval Committee":"CDA Interview Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":1328211},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-308719_Z_23_Z","data":{"id":"360G-Wellcome-308719_Z_23_Z","title":"Open Access Award 2024  ","Region":"London","currency":"GBP","awardDate":"2024-01-19T00:00:00+00:00","Internal ID":"308719/Z/23/Z","description":"No description available","plannedDates":[{"endDate":"2024-12-31T00:00:00+00:00","startDate":"2024-01-01T00:00:00+00:00"}],"amountAwarded":156218,"Financial Year":"2023/24","Lead Applicant":"Prof Liam Smeeth","grantProgramme":[{"title":"Open Access Award"}],"Applicant Surname":"Smeeth","Approval Committee":"Open Access Block Award recommendation meeting","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":156218},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-309748_Z_24_Z","data":{"id":"360G-Wellcome-309748_Z_24_Z","title":"Characterisation of Cardiovascular Disease in African youth with perinatally- acquired HIV infection in the era of antiretroviral therapy  ","Region":"London","currency":"GBP","awardDate":"2024-07-31T00:00:00+00:00","Sponsor(s)":"Dr Anoop Shah","Internal ID":"309748/Z/24/Z","description":"Antiretroviral therapy has increased survival in people with HIV. Children with perinatally-acquired HIV are now reaching adulthood in growing numbers. It is becoming increasingly apparent that despite ART, young people with perinatally-acquired HIV (YWH) experience multi-system comorbidities, which result in considerable disability. Cardiac disease is one of the most common comorbidities among African YWH and has often been investigated using transthoracic echocardiography (TTE). Whilst TTE provides information on myocardial function, it remains insensitive to detect tissue-level pathology such as fibrosis or oedema and does not provide any information on presence and extent of coronary artery disease (CAD). In adults, HIV-associated cardiac disease is believed to be driven by atherosclerosis, but studies have not established this in YWH. My fellowship will interrogate the hypothesis that in YWH, cardiac disease is due to a primary myocardial pathology and not due to CAD. I will conduct a cohort study using state-of-the-art advanced imaging techniques including cardiac magnetic resonance and computed tomography coronary angiography, combined with biochemical profiling, to characterise cardiac pathology, including the presence and extent of CAD, in YWH aged 17-27 years, presenting with an echocardiography abnormality. YWH will be followed- up at 24 months to investigate progression of cardiac pathology.","plannedDates":[{"endDate":"2029-12-31T00:00:00+00:00","startDate":"2025-01-01T00:00:00+00:00"}],"amountAwarded":819293,"Financial Year":"2023/24","Lead Applicant":"Edith Delewe Majonga","grantProgramme":[{"title":"Early-Career Award"}],"Applicant Surname":"Majonga","Approval Committee":"ECA Interview Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"Yes","Total amount including partnership funding":819293},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-309772_Z_24_Z","data":{"id":"360G-Wellcome-309772_Z_24_Z","title":"Assessing the effectiveness of Heat Adaptation & Heat Reduction Interventions for vulnerable population in urban and rural settings of a low- and middle- income country  ","Region":"London","currency":"GBP","awardDate":"2022-11-29T00:00:00+00:00","Internal ID":"309772/Z/24/Z","description":"Climate change has resulted in increased average global temperatures and increased number, duration and intensity of extreme heat events with South Asia emerging as one of the worst affected regions. The objectives of this study are to 1)synthesize global evidence-base of community interventions for heat adaptation/reduction strategies; 2)conduct an assessment of feasibility and acceptance of possible interventions through community participation and pilot testing; 3)evaluate a heat adaptation and reduction bundle (HAB) comprising of education, behavioural change and incentivized structural interventions through a cluster randomized controlled trial(cRCT). The intervention will be implemented in a representative urban and rural setting of Pakistan and target children, women including pregnant women, and other vulnerable adult labourers and elderly. The cRCT will primarily evaluate the impact of HAB on heat-related illnesses and a range of secondary outcomes including standardized heat measurements at household level, physiological strain, dehydration, thermal comfort/sensation, sleep hygiene, pregnancy outcomes (gestational weight gain, low birthweight, preterm births, stillbirths), mental health and overall cost effectiveness 4)assess the feasibility, and generalisability of scaling up the trial findings. This project will emphasize capacity building and gender equity and findings will be disseminated to relevant policy makers and researchers globally for potential uptake in other LMICs.","plannedDates":[{"endDate":"2028-03-03T00:00:00+00:00","startDate":"2024-03-04T00:00:00+00:00"}],"amountAwarded":0,"Financial Year":"2022/23","Lead Applicant":"Dr Ana Bonell","grantProgramme":[{"title":"Directed Call"}],"Applicant Surname":"Bonell","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":0},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-310728_Z_24_Z","data":{"id":"360G-Wellcome-310728_Z_24_Z","title":"Creating evidence to support tuberculosis (TB) national and global decision- makers in reducing the global burden of TB  ","Region":"London","currency":"GBP","awardDate":"2024-05-10T00:00:00+00:00","Internal ID":"310728/Z/24/Z","description":"TB is a leading global cause of death. Drug-resistant (DR)-TB causes a disproportionately large health and economic burden. New adolescent/adult TB vaccines are in phase 2b/3 trials, but implementation will be challenging, as is identifying the optimal choice of anti-TB interventions to make the best use of limited resources. In strong collaboration, we (India, South Africa, Brazil, Indonesia, UK) will create evidence to strengthen capacity and sustainably support high tuberculosis (TB) burden countries (HBC) and global decision-makers in reducing the global burden of TB, by using modelling tools to address key questions on drug-resistant (DR-)TB, new TB vaccines and other interventions, and extend and apply a state-of-the-art TB model, to estimate the relative health, cost-effectiveness, and budget impact, of new and existing interventions, as well as their optimal combination. The evidence created in the project will strengthen capacity and sustainably inform national and global decision-makers, including the governments of India, South Africa, Brazil and Indonesia (representing 40% of global TB), WHO, GAVI, and GFATM, to more rapidly reduce the global burden of TB.","plannedDates":[{"endDate":"2028-07-31T00:00:00+00:00","startDate":"2024-08-01T00:00:00+00:00"}],"amountAwarded":3470986,"Financial Year":"2023/24","Lead Applicant":"Prof Richard G White","grantProgramme":[{"title":"Discretionary Award"}],"Applicant Surname":"White","Approval Committee":"Discretionary Award decision meeting","Other Applicant(s)":"Dr Marcio Natividade, Prof Sri Rezeki Hadinegoro, Prof Sarika Mehra, Dr Salome Charalambous, Dr Mmamapudi Kubjane, Mrs Nugroho Soeharno, Prof Gwenan Mary Knight, Prof Auliya A. Suwantika, Prof Julio Croda, Prof Rein M G J Houben","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"Yes","Total amount including partnership funding":3470986},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-314747_Z_24_Z","data":{"id":"360G-Wellcome-314747_Z_24_Z","title":"Predictive Modelling for stillbirths and neonatal deaths in Sub-Saharan Africa  ","Region":"London","currency":"GBP","awardDate":"2024-11-30T00:00:00+00:00","Internal ID":"314747/Z/24/Z","description":"This project aims to address the high rates of stillbirths and neonatal deaths in Sub-Saharan Africa (SSA) by leveraging predictive modelling, including classical methods, machine learning (ML), and Artificial Intelligence (AI). SSA accounts for 47% global stillbirths and 46% neonatal deaths. Many SSA countries will unlikely meet their Sustainable Development Goals and Every Newborn Action Plan targets by 2030 due to poor quality of care, inadequate preventive measures, and data gaps. Current approaches are insufficient, but data science methodologies could mitigate these adverse outcomes. Using datasets from health-facilities and population studies across 15 African countries, I will develop robust predictive models for stillbirths and neonatal deaths. Advances in ML and AI are timely and can significantly improve predictions accuracy. Prediction models can enhance precision public health and resource efficiency, informing policy, planning, and clinical practice, ultimately reducing preventable stillbirths and neonatal deaths. Collaborations with academics, healthcare providers, and policymakers will ensure findings translate into actionable strategies. Outputs will include peer-reviewed publications, open-access datasets, and analytical tools, providing a framework for future research by integrating modern AI and ML techniques in SSA. Keywords: Stillbirths, Neonatal deaths, Predictive modelling, Machine learning, Artificial intelligence, Data science, Africa, Maternity registries, Demographic and Health Survey","plannedDates":[{"endDate":"2027-01-31T00:00:00+00:00","startDate":"2025-02-01T00:00:00+00:00"}],"amountAwarded":239320.97,"Financial Year":"2024/25","Lead Applicant":"Dr Akuze Joseph Waiswa","grantProgramme":[{"title":"Wellcome Accelerator Awards"}],"Applicant Surname":"Waiswa","Approval Committee":"Accelerator Awards Advisory Committee","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":"239320.97"},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-318370_Z_24_Z","data":{"id":"360G-Wellcome-318370_Z_24_Z","title":"Vocabularies of health and psychosocial support in the context of conflict, displacement, and diaspora  ","Region":"London","currency":"GBP","awardDate":"2024-09-10T00:00:00+00:00","Internal ID":"318370/Z/24/Z","description":"Conflict fundamentally affects people’s lives. Many lose homes and families, and must leave everything behind to survive. Relocation is seldom a one-off event, with compounded and understudied impacts on individuals and communities, especially those who must move multiple times. These are common experiences in the context of ongoing conflicts in Syria, Yemen, and Palestine, where protracted conflict has forced internal and external mobilities. We examine this as a public health issue, in terms of how best to articulate experiences and provide psychosocial support for conflict-induced migrants across the mobility spectrum, taking a transdisciplinary approach to research coalition building, conduct, and dissemination. Given the limitations of current mental health models for these communities, we seek to develop relevant understanding for this and comparable contexts.","plannedDates":[{"endDate":"2025-07-31T00:00:00+00:00","startDate":"2024-11-01T00:00:00+00:00"}],"amountAwarded":38706,"Financial Year":"2023/24","Lead Applicant":"Dr Natasha Howard","grantProgramme":[{"title":"Discretionary Award"}],"Applicant Surname":"Howard","Approval Committee":"Discretionary Award decision meeting","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":38706},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-318536_Z_24_Z","data":{"id":"360G-Wellcome-318536_Z_24_Z","title":"Co-designing an infection prevention and control intervention with staff and families in a Zimbabwean neonatal unit  ","Region":"London","currency":"GBP","awardDate":"2024-09-30T00:00:00+00:00","Sponsor(s)":"Dr Hannah Blencowe","Internal ID":"318536/Z/24/Z","description":"Background: Neonatal sepsis is a leading cause of neonatal mortality globally. The greatest burden of neonatal sepsis is in low- and middle-income countries (LMICs). In LMIC neonatal units (NNUs), healthcare-associated pathogens are being increasingly identified as the causative agents of neonatal sepsis. Effective reduction of neonatal sepsis rates is challenging due to limitations in infection prevention and control (IPC) within healthcare settings. The evidence base for effective IPC interventions in LMIC NNUs is limited. There is unexplored potential for families to contribute to IPC interventions, given their constant presence in NNUs and hands-on care for their newborn. Hypothesis: A co-design approach will create an IPC intervention that is acceptable and feasible within a Zimbabwean tertiary NNU. Methods 1\\. I will carry out a situational analysis to evaluate the organisational, infrastructural, and behavioural factors relating to IPC in a Zimbabwean NNU, including ethnographic observation, detailed observations and semi-structured interviews. 2\\. I will co-design an IPC intervention with staff members and families, using Experience Based Co-Design and the process of co-design will be evaluated for acceptability and fidelity. 3\\. The intervention will be piloted in a Zimbabwean neonatal unit over 6 months with concomitant process evaluation.","plannedDates":[{"endDate":"2027-05-24T00:00:00+00:00","startDate":"2023-09-25T00:00:00+00:00"}],"amountAwarded":0,"Financial Year":"2023/24","Lead Applicant":"Lydia Davidson","grantProgramme":[{"title":"PhD Studentship for Health Professionals"}],"Applicant Surname":"Davidson","Approval Committee":"Discretionary Award decision meeting","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":0},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-319121_Z_24_Z","data":{"id":"360G-Wellcome-319121_Z_24_Z","title":"ARTFUL AGEING: Investigating ageing mechanisms in children growing up with HIV in the era of antiretroviral therapy  ","Region":"London","currency":"GBP","awardDate":"2025-05-19T00:00:00+00:00","Internal ID":"319121/Z/24/Z","description":"We will determine how the mechanisms underlying biological ageing limit trajectories of growth, physical and cognitive function in children growing up with HIV. Despite antiretroviral therapy (ART) successes, children with HIV (CWH) commonly experience multi-system comorbidities limiting growth, physical and cognitive function, with phenotypes reminiscent of those seen in older adults. In older adults, Geroscience has identified a discrete set of hallmarks of biological ageing (primary, antagonistic and integrative) responsible for a common systemic susceptibility to disease. We hypothesize that perinatally-acquired HIV infection causes Accelerated Biological Ageing in children which drives poorer long-term health and development. Within a 24-month prospective cohort study recruiting 800 children aged 6-9 years in Harare (400 CWH on ART, and 400 HIV-negative and unexposed), our objectives are to: 1\\. Quantify domain-specific deficits (growth, physical, cognitive) in CWH, compared to their uninfected peers, longitudinally. 2\\. Characterise hallmarks of biological ageing in children with and without HIV. 3\\. Determine the role of accelerated hallmarks of biological ageing in explaining domain- specific deficits longitudinally in CWH. 4\\. Identify gero-protectors and gero-drivers potentially amenable to future therapeutic interventions. Our innovative South-North consortium melds HIV physicians, paediatricians, geriatricians and experts in geroscience to ‘Discover the Science’ behind paediatric HIV-associated ageing.","plannedDates":[{"endDate":"2033-03-31T00:00:00+00:00","startDate":"2026-04-01T00:00:00+00:00"}],"amountAwarded":4800000,"Financial Year":"2024/25","Lead Applicant":"Prof Rashida Abbas Ferrand","grantProgramme":[{"title":"Discovery Award"}],"Applicant Surname":"Ferrand","Approval Committee":"DSV Interview Committee","Other Applicant(s)":"Prof Caroline L Relton, Dr Hannah Rebecca Elliott, Prof Celia L Gregson, Prof Thomas Andrew Jackson, Prof Laura D Howe, Prof Susanna Jane Dunachie, Mr Tafadzwa Madanhire, Dr Nyasha Veronica Dzavakwa, Dr Barbara Kronsteiner-Dobramysl, Ms Tsitsi Bandason","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":4800000},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-320187_Z_24_Z","data":{"id":"360G-Wellcome-320187_Z_24_Z","title":"“Breaking the inverse laws”: Accelerating the health equity impact of prevention and control interventions for infectious diseases in Africa  ","Region":"London","currency":"GBP","awardDate":"2025-05-19T00:00:00+00:00","Internal ID":"320187/Z/24/Z","description":"Despite their potential to accelerate infectious disease prevention and control, health innovations often exacerbate rather than reduce health inequity, both between countries and within them. As researchers and practitioners working in the region most affected by infectious disease, sub- Saharan Africa, we are frustrated when richer countries and more advantaged groups are better enabled to take advantage of new technologies, compounding patterns of infectious disease risk and poorer access to health services among disadvantaged populations. We refer to the combined forces underpinning these repeated experiences as \"the inverse laws\". Determinants include structural factors, markets, health policies, programme implementation, behavioural and social factors and epidemiological dynamics. These determinants interact in complex ways, unique to infections, limiting the utility of existing health equity frameworks. But, the inverse laws are not inevitable. Counter-cases are found. The determinants are modifiable. We will use interdisciplinary, theory- informed analysis to interpret historical patterns and possible future trends, developing a new infectious disease health equity framework. We will conduct mixed-method, country-level case studies to investigate how to “break the inverse laws” for four major infectious diseases: HIV, HPV, measles and outbreak-prone infections. Findings will be actionable, disseminated through a cross-sectoral community of practice to ensure new advances benefit all.","plannedDates":[{"endDate":"2030-04-30T00:00:00+00:00","startDate":"2025-11-01T00:00:00+00:00"}],"amountAwarded":3599912,"Financial Year":"2024/25","Lead Applicant":"Prof James R Hargreaves","grantProgramme":[{"title":"Discovery Award"}],"Applicant Surname":"Hargreaves","Approval Committee":"DSV Interview Committee","Other Applicant(s)":"Dr Ruoran Li, Dr Mwelwa Muleba Phiri, Dr Ruoran Li, Ms Jessica M Ochalek, Dr Elizabeth Fearon, Prof Frank Courteney Tanser, Prof Shelley S Lees, Prof Ed Clarke, Ms Primrose Matambanadzo","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"Yes","Total amount including partnership funding":3599912},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-320877_Z_24_Z","data":{"id":"360G-Wellcome-320877_Z_24_Z","title":"Not enough and too many: professional personhood among Africa's paradoxically surplus health workers  ","Region":"London","currency":"GBP","awardDate":"2025-05-19T00:00:00+00:00","Internal ID":"320877/Z/24/Z","description":"By 2030, it is anticipated that Africa will face a shortage of nearly 6.1 million health workers. Simultaneously, approximately 700,000 health workers on the continent are expected to be without formal employment. Under current projections, this paradoxical surplus of health workers will comprise almost a quarter of Africa’s health workforce. \"Not Enough and Too Many\" is a bold mixed-methods study across West, East and Southern Africa. It asks: what are the global, national and local contingencies that have led to this paradoxical surplus; what are the consequences for individuals and services; and how can we enable the incorporation of this surplus into health systems? Drawing together scholars and methods from anthropology and public health, we will explore how unemployment, underemployment and precarious employment among health workers intersects with personhood and socio-economic relations; map the informal livelihood opportunities offered by pluralistic health systems; and examine the political economy underpinning policy on health worker employment in Uganda, Nigeria and Zambia. Our ultimate goals are to change narratives so that the paradoxical surplus of health workers takes its place as a critical issue in global health, and to support collaborations between academics, policy-makers, activists and health workers to reverse the trend.","plannedDates":[{"endDate":"2030-08-31T00:00:00+00:00","startDate":"2025-09-01T00:00:00+00:00"}],"amountAwarded":2559999,"Financial Year":"2024/25","Lead Applicant":"Dr Eleanor Hutchinson","grantProgramme":[{"title":"Discovery Award"}],"Applicant Surname":"Hutchinson","Approval Committee":"DSV Interview Committee","Other Applicant(s)":"Dr Sanny Mulubale, Prof Chidi Hyginus Ugwu, Dr Freddy Eric Kitutu","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":2559999},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-320878_Z_24_Z","data":{"id":"360G-Wellcome-320878_Z_24_Z","title":"CONNECT - Cohort and environmental data integration for epidemiological innovation  ","Region":"London","currency":"GBP","awardDate":"2025-05-19T00:00:00+00:00","Internal ID":"320878/Z/24/Z","description":"While the world faces an escalating climate crisis, our knowledge of the health risks of environmental stressors and climate change remains limited. CONNECT will bridge recent advances in geospatial modelling and health data infrastructure to revolutionise the research context in this field. The project, led by the EHM-Lab at LSHTM, is built on a well-structured research programme. First, novel GIS and machine-learning techniques will be applied to reconstruct hyper-resolution maps of environmental and climatic stressors across the UK. The team will then develop an innovative linkage scheme as well as cutting-edge statistical and computational techniques to integrate and analyse these data within the major large-scale UK cohort platforms. Various applications of the framework will be demonstrated in real-data case studies. Finally, methodologies, data, and training material will be released in open- access repositories and tutorials. This work will connect detailed individual- level measures of environmental exposures and physical environment with socio- economic indicators, medications and therapies, health events/conditions, and metabolic/genomic profiles in cohorts of millions of patients/participants. These resources will unlock unparalleled opportunities to address knowledge gaps, allowing investigations of complex mechanisms linking environment, climate, and health, and eventually informing public health and climate policies, reshaping this research field for decades to come.","plannedDates":[{"endDate":"2032-09-30T00:00:00+00:00","startDate":"2025-10-01T00:00:00+00:00"}],"amountAwarded":2501393,"Financial Year":"2024/25","Lead Applicant":"Prof Antonio Gasparrini","grantProgramme":[{"title":"Discovery Award"}],"Applicant Surname":"Gasparrini","Approval Committee":"DSV Interview Committee","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":2501393},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-321702_Z_24_Z","data":{"id":"360G-Wellcome-321702_Z_24_Z","title":"Quantifying childhood cancer burden in Tanzania: optimising use of multi- hospital electronic datasets and implications for cancer care and outcomes  ","Region":"London","currency":"GBP","awardDate":"2025-07-15T00:00:00+00:00","Sponsor(s)":"Prof Bernard Rachet","Internal ID":"321702/Z/24/Z","description":"Childhood cancer incidence in Africa is estimated to be similar to that of childhood malaria and twice as high as HIV, but without supportive care priority. By 2050, Africa will bear 50% of the global childhood cancer burden, making urgent action critical. Despite being curable in high-income countries, 5-year survival is only 8% in East-Africa, compared to 90% in the UK. Limited comprehensive data makes it difficult to assess the respective roles of detection, diagnosis, and treatment in poor outcomes. National childhood surveillance programme is required to achieve the World Health Organisation’s target of increasing childhood cancer 5-year survival to at least 60% by 2030. This project will generate the first quantification of Tanzania’s childhood cancer burden, its determinants, and drivers of poor outcomes by optimising a multi-hospital electronic health record system. I will achieve this by (1) using state-of-the-art epidemiological and statistical techniques to maximise data use; (2) and developing actionable recommendations for sustaining childhood cancer epidemiologic surveillance. Project outputs include an interactive dashboard reporting key indicators (e.g., incidence, mortality, and survival) to guide clinicians and public health interventions. The project will lay a foundation for ongoing surveillance, supporting efforts to reduce preventable cancer deaths in Tanzania and beyond.","plannedDates":[{"endDate":"2030-12-31T00:00:00+00:00","startDate":"2026-01-01T00:00:00+00:00"}],"amountAwarded":836555,"Financial Year":"2024/25","Lead Applicant":"Dr Wende Clarence Safari","grantProgramme":[{"title":"Early-Career Award"}],"Applicant Surname":"Safari","Approval Committee":"ECA Interview Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":836555},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-324097_Z_25_Z","data":{"id":"360G-Wellcome-324097_Z_25_Z","title":"Open Access Award 2025  ","Region":"London","currency":"GBP","awardDate":"2024-12-31T00:00:00+00:00","Internal ID":"324097/Z/25/Z","description":"No description available","plannedDates":[{"endDate":"2025-12-31T00:00:00+00:00","startDate":"2025-01-01T00:00:00+00:00"}],"amountAwarded":165292,"Financial Year":"2024/25","Lead Applicant":"David Archer","grantProgramme":[{"title":"Open Access Award"}],"Applicant Surname":"Archer","Approval Committee":"Open Access Block Award recommendation meeting","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":165292},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-324265_Z_25_Z","data":{"id":"360G-Wellcome-324265_Z_25_Z","title":"Characterising colonisation and transmission of Multi-Drug Resistant Gram- negative organisms in maternal care in Uganda - GRam negative Resistance In Pregnancy (GRIP).  ","Region":"London","currency":"GBP","awardDate":"2025-06-12T00:00:00+00:00","Sponsor(s)":"Prof Jaime Vera, Prof Gail Davey","Internal ID":"324265/Z/25/Z","description":"Infection is a common cause of maternal and neonatal death in Africa, and both mother and child are at increased risk of healthcare-associated infections (HAI). Multi-drug resistant Gram-negative bacteria (MDR-GNB) have acquired non-susceptibility to at least one agent in three or more antimicrobial categories, severely limiting treatment options. Antimicrobial resistance (AMR) is a threat to the health of pregnant women and infants. Colonisation with MDR-GNB bacteria may precede infection. The hospital environment can serve as reservoir for MDR-GNB, with a clean healthcare environment preventing colonisation and infection. The frequency of pregnant and postpartum women’s colonization with MDR-GNB during healthcare encounters and the hospital environment’s role in transmission pathways is poorly understood. Understanding the extent of MDR-GNB contamination in hospital environments can set benchmarks for monitoring and evidence-based cleaning standards, averting outbreaks and HAI. I aim to characterise the prevalence of colonisation with MDR-GNB in a cohort of pregnant women and neonates in Uganda and investigate the role of the hospital environment in acquisition of MDR-GNB around the time of delivery. I will identify and develop context appropriate, effective cleaning tools and assess their impact on MDR-GNB burden, developing context- appropriate environmental hygiene standards applicable to healthcare facilities across Africa","plannedDates":[{"endDate":"2027-11-02T00:00:00+00:00","startDate":"2024-11-03T00:00:00+00:00"}],"amountAwarded":0,"Financial Year":"2024/25","Lead Applicant":"Dr Lauren Hookham","grantProgramme":[{"title":"PhD Studentship for Health Professionals"}],"Applicant Surname":"Hookham","Approval Committee":"Discretionary Award decision meeting","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":0},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-324545_Z_25_Z","data":{"id":"360G-Wellcome-324545_Z_25_Z","title":"The transmission dynamics of Streptococcus pyogenes within the classrooms, households and environment of primary school-aged children in The Gambia.  ","Region":"London","currency":"GBP","awardDate":"2025-06-12T00:00:00+00:00","Sponsor(s)":"Prof Michael Marks","Internal ID":"324545/Z/25/Z","description":"Group A Streptococcus (GAS) has a large global burden. The dynamics of acquisition for both infection and asymptomatic colonisation are unknown, yet essential to understand for designing and assessing future preventative interventions. I will conduct an 8-month cohort study of primary school-aged pupils from three classes in The Gambia, to describe the patterns and determinants of GAS transmission. Fortnightly throat and skin swabs will be cultured and GAS confirmed by MALDI-TOF. Cough plates will be taken from all clinical cases of pharyngitis and wound swabs from pyoderma. Reactive classroom and index-case household surveys will be conducted, with classroom environmental sampling. All samples will undergo quantitative polymerase chain reaction (qPCR), with downstream emm-typing and whole genome sequencing (WGS) of detected GAS. Primary objectives: 1) To establish an accurate prevalence and incidence of pharyngeal and skin infection and asymptomatic colonisation of GAS in primary school-aged children in The Gambia. 2) To calculate the secondary attack rate of GAS infection/colonisation, through temporal and molecular linkage, in classmates and household members of index cases of pharyngitis and pyoderma. 3) To investigate whether bacterial load in the pharynx or skin is a driver of onward transmission and/or environmental detection, comparing symptomatic cases with asymptomatic colonisation.","plannedDates":[{"endDate":"2028-05-05T00:00:00+00:00","startDate":"2024-11-06T00:00:00+00:00"}],"amountAwarded":0,"Financial Year":"2024/25","Lead Applicant":"Dr Edward Monk","grantProgramme":[{"title":"PhD Studentship for Health Professionals"}],"Applicant Surname":"Monk","Approval Committee":"Discretionary Award decision meeting","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":0},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-324905_Z_25_Z","data":{"id":"360G-Wellcome-324905_Z_25_Z","title":"Advancing social media data science to examine the causal relationship between social media content and adolescent health-risk behaviours  ","Region":"London","currency":"GBP","awardDate":"2025-07-15T00:00:00+00:00","Sponsor(s)":"Prof Mark Petticrew, Prof Amy Orben","Internal ID":"324905/Z/25/Z","description":"Social media platforms like TikTok may negatively shape adolescents' health behaviours, contributing to health inequalities. Exposure to alcohol, drug use, and anti-social behaviour (ADA) content on social media correlates with increased offline engagement in these behaviours. However, existing research relies on biased measures (e.g., time-use diaries, self-reports), which fail to capture the complexity of content exposure, limiting causal claims and evidence-based policy. Guided by a Policy Advisory Group - including stakeholders from Ofcom, the Department for Science, Innovation, and Technology - and Youth Advisory Groups, this project aims to address critical policy priorities by: (1) Developing innovative methodologies to accurately measure real-time social media content exposure by using a hybrid human- generative AI approach to identify ADA-content in TikTok data donations (obtained via the TikTok Application Programming Interface) combined with Ecological Momentary Assessment. (2) Assessing the causal effects of ADA- content on offline ADA-behaviours in adolescents (ages 13-24) from the socioeconomically and ethnically diverse Born in Bradford Age of Wonder and SmartHealth Young Adult Studies. Ultimately, the project will integrate public voices for real-world impact, inform public health strategies and legislation, and advance knowledge via a public engagement campaign featuring influential figures (i.e., United Nations, Idris Elba), high-impact publications, and policy briefings.","plannedDates":[{"endDate":"2031-02-26T00:00:00+00:00","startDate":"2026-02-27T00:00:00+00:00"}],"amountAwarded":753083,"Financial Year":"2024/25","Lead Applicant":"Dr Amrit Kaur Purba","grantProgramme":[{"title":"Early-Career Award"}],"Applicant Surname":"Purba","Approval Committee":"ECA Interview Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"Yes","Research conducted at multiple locations?":"Yes","Total amount including partnership funding":753083},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-327785_Z_25_Z","data":{"id":"360G-Wellcome-327785_Z_25_Z","title":"ANH Academy Week bursary support  ","Region":"London","currency":"GBP","awardDate":"2025-04-01T00:00:00+00:00","Internal ID":"327785/Z/25/Z","description":"Since 2015, the Agriculture, Nutrition & Health (ANH) Academy has evolved into a global community of over 11,000 members from 160 countries, working towards sustainable and equitable food systems. Nearly 70% of members are based in Africa and Asia, with over 60% being women. The key objectives of the ANH Academy are to: \\- Build an interdisciplinary community to share innovative research. \\- Develop and harmonize new research. \\- Strengthen and share research capacity. \\- Facilitate the uptake of evidence in policies and programs. The key activities are: \\- ANH Academy Week: The flagship biannual event featuring learning labs, research conferences, and side events. \\- Working Groups: Accelerate research by sharing methods and approaches. \\- Skills-Based Trainings: Offered via face-to-face gatherings and webinars. \\- Support Center for Agriculture and Nutrition Research (SCANR). \\- Curriculum Resources: For educators in higher education. The 10th annual ANH Academy Week will be held in Tanzania in June 2025, featuring workshops, a research conference, and plenary sessions focused on climate change and health. Given the rise in participation, the Wellcome Trust is invited to consider supporting researchers from low- and middle-income countries.","plannedDates":[{"endDate":"2025-08-31T00:00:00+00:00","startDate":"2025-05-01T00:00:00+00:00"}],"amountAwarded":160000,"Financial Year":"2024/25","Lead Applicant":"Prof Suneetha Venkata Kadiyala","grantProgramme":[{"title":"Discretionary Award"}],"Applicant Surname":"Kadiyala","Approval Committee":"Discretionary Award decision meeting","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":160000},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-328709_Z_25_Z","data":{"id":"360G-Wellcome-328709_Z_25_Z","title":"Africa Oculomics Research Programme: harnessing ocular biomarkers to transform health  ","Region":"London","currency":"GBP","awardDate":"2025-09-02T00:00:00+00:00","Internal ID":"328709/Z/25/Z","description":"Our vision is to unlock the potential of Oculomics to better understand, predict, diagnose and manage systemic and ocular disease, to improve health outcomes and equity for African populations. Oculomics is the emerging field of study into relationships between the eyes and systemic health and disease. It is being transformed by advances in high-resolution ocular imaging coupled with recent advances in artificial intelligence (AI), particularly deep learning. We will conduct ocular phenotyping and imaging studies, repeated five years apart, nested within an existing general population cohort in Uganda. In parallel we will collect clinical, laboratory and image phenotyping data for systemic health states (cardiovascular, neurological, renal, liver, musculoskeletal, mental health), alongside genotyping data. We will use these data to develop, tune and validate AI foundation models to analyse images from this African population for multiple systemic disease and ocular diagnostic tasks. We will investigate cross-sectional and longitudinal relationships between ocular biomarkers and major health conditions, to determine their diagnostic, prognostic and predictive potential. Finally, we will conduct prospective studies to investigate the utility of oculomics supported diagnostics in general health care settings, assessing the suitability and performance of AI-assisted diagnosis, when paired with novel low-cost imaging equipment.","plannedDates":[{"endDate":"2034-02-28T00:00:00+00:00","startDate":"2026-02-01T00:00:00+00:00"}],"amountAwarded":4472832,"Financial Year":"2024/25","Lead Applicant":"Prof Matthew J Burton","grantProgramme":[{"title":"Discovery Award"}],"Applicant Surname":"Burton","Approval Committee":"DSV Interview Committee","Other Applicant(s)":"Prof Moffat J Nyirenda, Prof Annettee Olivia Nakimuli, Prof Pearse Andrew Keane, Dr Simon Arunga","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":4472832},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-329623_Z_25_Z","data":{"id":"360G-Wellcome-329623_Z_25_Z","title":"Tackling the Risks of Aflatoxins and Climate Effects on Child Health in Africa (TRACE)  ","Region":"London","currency":"GBP","awardDate":"2025-08-06T00:00:00+00:00","Internal ID":"329623/Z/25/Z","description":"Our proposal, TRACE, addresses a neglected challenge affecting millions of households in Africa at the intersection of climate change, food safety, and child health. Aflatoxins, toxins produced by fungi in staple crops such as maize and peanuts, pose a growing threat as climate change creates conditions that favour contamination. Exposure has been linked to impaired immunity and malnutrition in children, heightening vulnerability to infections. However, direct evidence remains limited, and aflatoxins are largely absent from climate and child health policy agendas, hindering implementation of mitigation measures. Within the first year of the award, we will connect two decades of climate data to aflatoxin exposure trends, generating the first large-scale empirical evidence of the climate-aflatoxin-child health link. We will then test an intervention package co-designed with communities in Kenya and The Gambia, measuring effects on aflatoxin exposure, acute febrile illness, and vaccine immune responses among children. We will model future health and economic risks under climate change scenarios to inform long-term solutions. Our transdisciplinary team integrates expertise in epidemiology, climate science, immunology, anthropology, food science, and policy engagement. Strong partnerships with communities, governments, and international agencies will ensure findings are rapidly and sustainably embedded into policy and local farming practices.","plannedDates":[{"endDate":"2029-02-28T00:00:00+00:00","startDate":"2026-03-01T00:00:00+00:00"}],"amountAwarded":2731498.3,"Financial Year":"2024/25","Lead Applicant":"Prof Ambrose Agweyu","grantProgramme":[{"title":"Climate Impacts Award"}],"Applicant Surname":"Agweyu","Approval Committee":"Climate Impacts Advisory Committee","Other Applicant(s)":"Prof Jia-Sheng Wang, Dr Neven Stjepan Fuckar, Dr James Jimmy Nyagwange, Prof Salome Bukachi, Dr Modou Jobe, Dr David Githanga","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":"2731498.3"},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-331655_Z_25_Z","data":{"id":"360G-Wellcome-331655_Z_25_Z","title":"Strengthening Adolescent Resilience to Improve Sexual and reproductive hEalth (ARISE) Uganda  ","Region":"London","currency":"GBP","awardDate":"2026-01-13T00:00:00+00:00","Sponsor(s)":"Prof Kara Hanson","Internal ID":"331655/Z/25/Z","description":"This study will generate new evidence on how resilience—defined as positive adaptation despite adversity—shapes sexual and reproductive health (SRH) outcomes among Ugandan adolescents aged 10–19. In Uganda, where adolescents comprise a quarter of the population, rates of HIV, STIs, and unintended pregnancy remain among the highest globally, posing a critical and urgent public health challenge. Drawing on my experience leading research on gender, violence, and adolescent SRH across sub-Saharan Africa, this study applies the Candidacy Framework in a novel way to examine how resilience is shaped, enacted, and constrained across social and structural contexts. Shifting from risk-focused paradigms, it foregrounds adolescents’ strengths—across individual, relational, community, and structural levels—and how these interact with gender and context to influence SRH trajectories. A rigorous mixed-methods design—including longitudinal and cross-sectional surveys, biological testing, participatory approaches, and qualitative methods—will generate generalisable data and deep insight into lived experience. This integrative approach supports nuanced, dynamic analysis of resilience over time. A context-specific tool to measure resilience will be developed and validated, contributing conceptual and empirical innovation. Strong ethical safeguards, youth-led engagement, and collaborative partnerships will ensure cultural relevance and impact. Findings will inform scalable, equity-focused policy and programming aligned to Ugandan and global adolescent health priorities.","plannedDates":[{"endDate":"2034-05-30T00:00:00+00:00","startDate":"2026-06-01T00:00:00+00:00"}],"amountAwarded":3385545,"Financial Year":"2025/26","Lead Applicant":"Dr Nambusi Kyegombe","grantProgramme":[{"title":"Career Development Award"}],"Applicant Surname":"Kyegombe","Approval Committee":"CDA Interview Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"Yes","Total amount including partnership funding":3385545},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-332863_Z_25_Z","data":{"id":"360G-Wellcome-332863_Z_25_Z","title":"NeoShield: Epidemiological Analysis of Neonatal Sepsis and Antimicrobial Resistance Dynamics to Inform Novel Detection Tools in High-Burden Settings  ","Region":"London","currency":"GBP","awardDate":"2025-09-30T00:00:00+00:00","Internal ID":"332863/Z/25/Z","description":"Neonatal healthcare-associated infections (HAIs) are a major cause of mortality and antimicrobial resistance (AMR) in healthcare facilities across sub-Saharan Africa. Of the 2.3 million neonatal deaths annually, an estimated 24% are infection-related, with many linked to outbreaks. Overstretched clinical teams, limited diagnostics, fragmented data, and critical gaps in local pathogen epidemiology and genomics often hinder outbreak detection and response. Integrated, context-appropriate solutions are urgently needed to link local microbiological surveillance to real-time, individual-level care. NeoShield will address these challenges in Malawi and Zambia by generating epidemiological and genomic data on neonatal HAIs and their associated AMR, and by developing and validating an AI-driven Clinical Decision Support Algorithm (CDSA) to support inpatient management of neonatal sepsis. The CDSA will integrate clinical signs, point-of-care diagnostics, and local microbiology trends to support antibiotic treatment decisions aligned with facility, national, and World Health Organisation (WHO) guidelines. Five workstreams will be delivered: (1) Laboratory Strengthening; (2) CDSA Development and Validation; (3) Ward-Level Outbreak Detection with Automated Alerts; (4) Sepsis and Stewardship Intervention Bundle; and (5) Pathogen Whole-Genome Sequencing. NeoShield will produce open-source digital tools, open-access learning resources, peer-reviewed publications, and policy briefs to inform national and global strategies for neonatal infection prevention and AMR surveillance.","plannedDates":[{"endDate":"2028-09-30T00:00:00+00:00","startDate":"2025-10-01T00:00:00+00:00"}],"amountAwarded":1627819.47,"Financial Year":"2024/25","Lead Applicant":"Prof Eric Ohuma","grantProgramme":[{"title":"Discretionary Award"}],"Applicant Surname":"Ohuma","Approval Committee":"Discretionary Award decision meeting","Other Applicant(s)":"Dr Patrick Musicha, Prof Roma Chilengi, Dr James Henry Cross","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":"1627819.47"},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-334348_Z_25_Z","data":{"id":"360G-Wellcome-334348_Z_25_Z","title":"Climate, Children, and Consequences: The Impact of Climate Change on Child Health in Southern Mozambique  ","Region":"London","currency":"GBP","awardDate":"2025-11-05T00:00:00+00:00","Internal ID":"334348/Z/25/Z","description":"As climate change intensifies, extreme heat is becoming a growing threat to health—particularly for young children in low and middle income countries. This project explores how rising temperatures affect child health in Mozambique, a country already facing high burdens of infectious disease, malnutrition, and health system strain. The research will investigate whether heatwaves and high temperatures are linked to increased hospital admissions for illnesses such as diarrhoea, respiratory infections, and fever in children under five. Using 15 years of hospital and climate data from Manhiça District, the project aims to identify patterns and risks, and to generate evidence that can inform health services and climate adaptation planning. The research also supports local collaboration, ensuring Mozambican voices and institutions are central in the design, analysis, and use of findings. The project is part of a broader effort to strengthen climate resilience in child health and contribute to global efforts to reduce climate-related health inequalities. Ultimately, this work will provide much-needed data for policymakers, clinicians, and communities seeking to protect children from the growing health risks of a warming world.","plannedDates":[{"endDate":"2027-12-01T00:00:00+00:00","startDate":"2025-12-01T00:00:00+00:00"}],"amountAwarded":318525,"Financial Year":"2025/26","Lead Applicant":"Dr Sham Lal","grantProgramme":[{"title":"Wellcome Accelerator Awards"}],"Applicant Surname":"Lal","Approval Committee":"Accelerator Awards Advisory Committee","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"Yes","Total amount including partnership funding":318525},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-335478_Z_25_Z","data":{"id":"360G-Wellcome-335478_Z_25_Z","title":"Integrating genomic, clinical and epidemiological data to better understand Mycobacterium tuberculosis transmission and emergence of drug resistance  ","Region":"London","currency":"GBP","awardDate":"2025-11-05T00:00:00+00:00","Internal ID":"335478/Z/25/Z","description":"The rapid emergence and transmission of Mycobacterium tuberculosis (M. tuberculosis) strains resistant to newer drugs, e.g. bedaquiline, threatens global tuberculosis care and prevention. Although drug-resistant tuberculosis accounts for 3% of cases, it consumes over 33% of the budget in South Africa. Research has largely focussed on host and environmental determinants, whilst the role of pathogen genomics in driving transmission and resistance remains under-explored, leaving a gap in knowledge needed to inform effective interventions. This Award will generate foundational insights into how M. tuberculosis lineage and resistance evolution influence transmission. It will accelerate my career by providing pathogen genomics training, enabling me to integrate my academic, clinical and implementation interests in drug-resistant tuberculosis and support the generation of pilot data to underpin a competitive application for a prestigious career development award. The Award will provide protected time to publish manuscripts arising from this work, support my transition to research independence, strengthen collaborations in the Global South and significantly raise my international visibility. By the end of this Award, I will be uniquely positioned to build a high-impact career as an interdisciplinary translational researcher contributing to transmission- cutting public health interventions and enabling precision-guided treatments to improve outcomes for people with drug-resistant tuberculosis.","plannedDates":[{"endDate":"2028-09-30T00:00:00+00:00","startDate":"2026-10-01T00:00:00+00:00"}],"amountAwarded":421926,"Financial Year":"2025/26","Lead Applicant":"Dr Palwasha Yousafzai Khan","grantProgramme":[{"title":"Wellcome Accelerator Awards"}],"Applicant Surname":"Khan","Approval Committee":"Accelerator Awards Advisory Committee","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":421926},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-337458_Z_25_Z","data":{"id":"360G-Wellcome-337458_Z_25_Z","title":"Improving mental health among Ugandan and Ghanaian adolescents through a school-based sleep health intervention: Better Sleep, Better Health  ","Region":"London","currency":"GBP","awardDate":"2026-03-02T00:00:00+00:00","Internal ID":"337458/Z/25/Z","description":"Insomnia can cause depression and anxiety in adolescents. Cognitive behavior therapy for insomnia (CBT-I) is an effective early intervention for depression and anxiety. Focusing on improving sleep can offer a non-stigmatising pathway to improve mental health, but CBT-I is not widely used due to lack of awareness of the importance of sleep for mental health, shortage of trained providers and non-existence of scalable resource-efficient delivery models. We will address the evidence gap of how to deliver CBT-I at scale to adolescents in Africa. In the Foundation Phase, we will build a partnership to design and evaluate scalable CBT-I-based interventions to improve the mental health of secondary school students in Africa. Objectives: 1) To establish a sustainable equitable partnership among researchers, implementation partners, lived- experience experts, WHO and the Ministries of Health and Education in Uganda and Ghana. 2) To adapt a CBT-I-based intervention to ensure scalability and sustainability in Uganda and Ghana, guided by May’s General Theory of Implementation and feasibility case-series. 3) To co-design a cluster- randomised controlled trial to evaluate the implementation, effectiveness, cost-effectiveness and sustainability of these CBT-I-based interventions to reduce depression and anxiety among secondary school students in Uganda and Ghana, using the RE-AIM evaluation framework.","plannedDates":[{"endDate":"2027-07-01T00:00:00+00:00","startDate":"2026-07-01T00:00:00+00:00"}],"amountAwarded":200000,"Financial Year":"2025/26","Lead Applicant":"Prof Helen Anne Weiss","grantProgramme":[{"title":"Directed call - Mental Health – Psychosocial Foundation Phase"}],"Applicant Surname":"Weiss","Approval Committee":"Mental Health Award: Transforming Early Intervention in Young People","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":200000},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-338565_Z_25_Z","data":{"id":"360G-Wellcome-338565_Z_25_Z","title":"INNOVETH: Innovative Health Intervention for Ethiopian Migrant Domestic Workers in the Middle East  ","Region":"London","currency":"GBP","awardDate":"2025-09-30T00:00:00+00:00","Internal ID":"338565/Z/25/Z","description":"Every year, more than 350,000 Ethiopian women migrate to the Middle East legally, and many others illegally, seeking domestic work. Economic crisis, rising unemployment, and internal conflict contribute to this massive migration. The bilateral agreement between the Ethiopian government and each destination country requires recruitment agencies to undertake rigorous pre- migration medical check-up for migrant domestic workers (MDWs). Nevertheless, MDWs in the Middle East are subject to overwork; mental, sexual and reproductive health challenges; and limited healthcare access. Studies on MDWs are mostly exploratory or cross-sectional; longitudinal and intervention studies are lacking. We propose to provide healthcare support to these vulnerable women by leveraging social networks, social media, and innovative technology. In Phase I, we explored key health challenges of MDWs through a scoping review, stakeholder consultation, and analysis of pre-migration data. We hypothesized that, by utilizing epidemiological and data science intelligence methods, we could stratify MDWs based on their level of risk and provide tailored intervention. We developed an intervention package, including training, peer-support and self-help groups, and mobile applications. In Phase II, we propose to i) develop, refine and validate a risk stratification tool, ii) refine and pilot the intervention and iii) implement and evaluate its impact and cost-effectiveness.","plannedDates":[{"endDate":"2029-10-31T00:00:00+00:00","startDate":"2025-11-01T00:00:00+00:00"}],"amountAwarded":425735.14,"Financial Year":"2024/25","Lead Applicant":"Dr Mohammed Sanni Ali","grantProgramme":[{"title":"Discretionary Award"}],"Applicant Surname":"Ali","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":"425735.14"},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-342887_Z_25_Z","data":{"id":"360G-Wellcome-342887_Z_25_Z","title":"Support for IPCC's 7th assessment report meetings  ","Region":"London","currency":"GBP","awardDate":"2025-12-05T00:00:00+00:00","Internal ID":"342887/Z/25/Z","description":"I will be lead author for WGIII chapter 4 and I expect to be attending 1 in person meeting per year.","plannedDates":[{"endDate":"2027-12-31T00:00:00+00:00","startDate":"2026-01-01T00:00:00+00:00"}],"amountAwarded":10504,"Financial Year":"2025/26","Lead Applicant":"Dr Pauline FD Scheelbeek","grantProgramme":[{"title":"Discretionary Award"}],"Applicant Surname":"Scheelbeek","Approval Committee":"Discretionary Award decision meeting","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":10504},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-343146_Z_25_Z","data":{"id":"360G-Wellcome-343146_Z_25_Z","title":"Open Access Award 2026  ","Region":"London","currency":"GBP","awardDate":"2025-12-15T00:00:00+00:00","Internal ID":"343146/Z/25/Z","description":"No description available","plannedDates":[{"endDate":"2026-12-31T00:00:00+00:00","startDate":"2026-01-01T00:00:00+00:00"}],"amountAwarded":202381,"Financial Year":"2025/26","Lead Applicant":"David Archer","grantProgramme":[{"title":"Open Access Award"}],"Applicant Surname":"Archer","Approval Committee":"Open Access Block Award recommendation meeting","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":202381},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-343250_Z_25_Z","data":{"id":"360G-Wellcome-343250_Z_25_Z","title":"CREATE PhD Programme  ","Region":"London","currency":"GBP","awardDate":"2026-06-12T00:00:00+00:00","Sponsor(s)":"Prof Thushan de Silva","Internal ID":"343250/Z/25/Z","description":"Respiratory viruses can increase bacterial colonisation, density, and secretion from the upper respiratory tract (URT), yet these interactions remain poorly understood—particularly in low- and middle-income countries (LMICs). Characterising these relationships is pivotal in formulating measures to mitigate secondary bacterial infections and bacterial transmission. To address these key knowledge gaps this study investigates the impact of respiratory viruses on the colonisation and transmission dynamics of Streptococcus pneumoniae, Staphylococcus aureus, and Streptococcus pyogenes in Gambian households. Using an existing longitudinal household dataset (TransVir), which includes over 14,000 oral/nasal swabs collected weekly from 349 participants across 52 households, I will: 1.​ Determine the impact of respiratory viruses on URT carriage and density of S. pneumoniae, S. aureus, and S. pyogenes using qPCR-based bacterial quantification. 2.​ Assess how respiratory viral infections influence household transmission of these bacteria using hidden Markov models. 3.​ Characterise virus-induced changes in the URT microbiome through metagenomic sequencing, evaluating shifts in microbial composition and strain-level dynamics. My preliminary analyses indicate that respiratory viruses such as RSV and rhinovirus increase pneumococcal colonisation risk, but SARS-CoV-2 does not. These findings will enhance understanding of viral-bacterial interactions and aims to inform viral and bacterial vaccination strategies and viral pandemic responses in LMICs.","plannedDates":[{"endDate":"2028-01-15T00:00:00+00:00","startDate":"2025-01-15T00:00:00+00:00"}],"amountAwarded":0,"Financial Year":"2025/26","Lead Applicant":"Jack William Goodall","grantProgramme":[{"title":"PhD Studentship for Health Professionals"}],"Applicant Surname":"Goodall","Approval Committee":"Discretionary Award decision meeting","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":0},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-343772_Z_26_Z","data":{"id":"360G-Wellcome-343772_Z_26_Z","title":"Integrated Climate, Food Systems, Nutrition and Health Research in LMICs: barriers, enablers and opportunities  ","Region":"London","currency":"GBP","awardDate":"2026-03-31T00:00:00+00:00","Internal ID":"343772/Z/26/Z","description":"Climate change and environmental degradation are shaping food systems, nutrition and health outcomes, especially in LMICs, while global food systems and diets are contributing to worsening planetary health. Despite growing recognition of these interconnections, research that empirically links these themes remains underdeveloped along many pathways and methodologically fragmented. We will produce an evidence-based needs assessment of the global research ecosystem at the climate–food systems–nutrition–health intersection, with a deliberate focus on LMIC researchers and institutions and their collaborators. We will identify and critically analyse the conceptual, data, capacity and structural barriers that currently limit generation of high- quality interdisciplinary research, alongside opportunities to catalyse research development. Using a mixed qualitative approach, we will (i) map data landscapes, availability and analytic capacities through desk review, and (ii) conduct expert consultation through semi-structured interviews with funders, reviewers and researchers, including applicants to climate–food–health research calls. The project will generate actionable recommendations to inform funders, policymakers and research leaders on how to align investments, strengthen enabling environments and promote interdisciplinary research. Outputs will include a peer-reviewed publication, validation exercise and stakeholder convenings to support a step-change in the generation of policy- relevant evidence linking climate change, food systems, nutrition and health.","plannedDates":[{"endDate":"2027-11-30T00:00:00+00:00","startDate":"2026-04-15T00:00:00+00:00"}],"amountAwarded":232779.6,"Financial Year":"2025/26","Lead Applicant":"Dr Thalia Sparling","grantProgramme":[{"title":"Discretionary Award"}],"Applicant Surname":"Sparling","Approval Committee":"Discretionary Award decision meeting","Other Applicant(s)":"Dr Edward Joy","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":"232779.6"},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-345503_Z_26_Z","data":{"id":"360G-Wellcome-345503_Z_26_Z","title":"Improving the Early Identification and Intervention of Disability-Related Feeding Difficulties amongst Young Children in Uganda  ","Region":"London","currency":"GBP","awardDate":"2026-06-12T00:00:00+00:00","Sponsor(s)":"Dr Femke Bannink Mbazzi","Internal ID":"345503/Z/26/Z","description":"**Research Goal:** To develop and evaluate a contextually relevant Integrated Clinical Care Pathway (ICCP) for early identification and intervention of disability-related feeding difficulties amongst young children (<3 years) with developmental disabilities in Uganda.  **Background:** Feeding difficulties affect up to 80% of children with developmental disabilities, contributing significantly to malnutrition and poor health outcomes, yet remain under-addressed in low-resource settings. Despite disproportionately affecting children in LMICs, there is limited guidance on identification and management approaches within healthcare systems.  **Methods:** This PhD research employs a participatory approach guided by implementation science frameworks. The research will be conducted across two government health centres and one specialist rehabilitation facility in western Uganda, enabling assessment across different healthcare contexts.  **Objectives:** (1) Conduct a scoping review of existing evidence on identification and intervention approaches; (2) Examine facilitators and barriers to accessing high-quality nutritional care through cross-sectional and qualitative assessment; (3) Co-design an ICCP through structured stakeholder workshops; and (4) Evaluate the ICCP's feasibility, acceptability and preliminary impact when implemented in government healthcare facilities.  This research addresses critical evidence gaps whilst developing a model for disability-inclusive healthcare that could be adapted across sub-Saharan Africa, ultimately improving nutritional outcomes for a frequently overlooked vulnerable population.","plannedDates":[{"endDate":"2028-12-31T00:00:00+00:00","startDate":"2026-01-01T00:00:00+00:00"}],"amountAwarded":0,"Financial Year":"2025/26","Lead Applicant":"Miss Fiona Mary Elizabeth Beckerlegge","grantProgramme":[{"title":"PhD Studentship for Health Professionals"}],"Applicant Surname":"Beckerlegge","Approval Committee":"Discretionary Award decision meeting","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":0},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-345549_Z_26_Z","data":{"id":"360G-Wellcome-345549_Z_26_Z","title":"Integrated nutritional care to improve outcomes amongst hospitalised adults with advanced HIV disease (IN-care)  ","Region":"London","currency":"GBP","awardDate":"2026-06-12T00:00:00+00:00","Sponsor(s)":"Prof Joseph Jarvis","Internal ID":"345549/Z/26/Z","description":"Advanced HIV disease (AHD, defined as CD4 20% (3), and 60% of PLWH admitted to hospital are malnourished (5). Energy requirements for PLWH compared to people without HIV are approximately 10% higher when asymptomatic, and 20-50% higher if symptomatic (6), despite this there are currently no guidelines on nutritional support for hospitalised adults with AHD. The aim of my fellowship is to describe nutritional status amongst hospitalised adults with AHD, investigate for associations with mortality, and to co-develop and pilot a feasible and acceptable nutritional intervention to improve outcomes. Objectives: 1\\. To understand and describe the current evidence in nutritional interventions for PLWH by conducting a systematic review. 2\\. To conduct a cohort study of 250 hospitalised adults with AHD to describe the burden of severe malnutrition and to investigate for associations with mortality. 3\\. To co-develop a feasible and acceptable nutritional-supplementation intervention. 4\\. To pilot and evaluate the co-developed intervention amongst 60 hospitalised adults with AHD.","plannedDates":[{"endDate":"2028-08-31T00:00:00+00:00","startDate":"2025-09-01T00:00:00+00:00"}],"amountAwarded":0,"Financial Year":"2025/26","Lead Applicant":"Gila Hale","grantProgramme":[{"title":"PhD Studentship for Health Professionals"}],"Applicant Surname":"Hale","Approval Committee":"Discretionary Award decision meeting","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":0},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-345726_Z_26_Z","data":{"id":"360G-Wellcome-345726_Z_26_Z","title":"Understanding Acquired Epidermodysplasia Verruciformis in Young People Living with HIV in Zimbabwe  ","Region":"London","currency":"GBP","awardDate":"2026-06-12T00:00:00+00:00","Sponsor(s)":"Prof Sinéad Langan","Internal ID":"345726/Z/26/Z","description":"Perinatally-acquired HIV results in early-life immune dysregulation. Historically this led to high mortality rates in childhood. Following the widespread availability of antiretroviral therapy (ART), increasing numbers of people with perinatally-acquired HIV survive into adulthood. Despite effective viral suppression with ART, immune system abnormalities persist, predisposing individuals to a range of comorbidities. One such condition is acquired epidermodysplasia verruciformis (aEV), a disorder characterised by disseminated cutaneous infection with beta human papillomaviruses (HPV). While beta-HPVs are ubiquitous and typically asymptomatic in immunocompetent individuals, some people with HIV can develop extensive and persistent flat warts and pityriasis versicolor-like lesions (aEV). Where the association with HIV is recognised, aEV is highly stigmatising. The associated HPV types, particularly HPV 5 and 8, are potentially oncogenic and there are emerging cases of skin cancer in young people with aEV. There are currently no clear diagnostic criteria and the epidemiology, risk factors, virological drivers, and quality of life impact of aEV in this population remain poorly understood. People with aEV are offered minimal information or support to help them navigate their condition. This study seeks to address these gaps. The findings will inform future research directions, guide clinical management strategies, and support the development of targeted interventions.","plannedDates":[{"endDate":"2028-12-31T00:00:00+00:00","startDate":"2026-01-01T00:00:00+00:00"}],"amountAwarded":0,"Financial Year":"2025/26","Lead Applicant":"Dr Sophie Helen Kelly","grantProgramme":[{"title":"PhD Studentship for Health Professionals"}],"Applicant Surname":"Kelly","Approval Committee":"Discretionary Award decision meeting","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":0},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-351087_Z_26_Z","data":{"id":"360G-Wellcome-351087_Z_26_Z","title":"Rethinking Misinformation, Health and Human Security  ","Region":"London","currency":"GBP","awardDate":"2026-06-25T00:00:00+00:00","Internal ID":"351087/Z/26/Z","description":"Misinformation and disinformation have been ranked by the World Economic Forum and United Nations as top global risks, above extreme weather, armed conflict, and cyber warfare. Their impact on health is severe and growing – from suspended clinical trials and the disruption of vaccination and other health programmes, to climate science denialism and the systematic erosion of trust in health institutions. Yet current response frameworks remain largely reactive and narrowly focused on correcting false information, when the most damaging narratives often operate through emotional manipulation, fear polarisation, undermining of trust, and distortion of perceived social norms - not explicit falsehoods. The Lancet Commission on “Rethinking Misinformation, Health and Human Security” will reframe the dominant understanding of misinformation and operationalise the concept of ‘signal distortion’ as an actionable framework and develop and test ways of intervening to enrich the integrity of the information ecosystem – identifying where and how to intervene to improve the overall quality of information ecosystems while working to build underlying trust. This approach is designed to be operationalised and to outlive the Commission. The Commission will generate clear, policy-targeted recommendations for the audiences best positioned to act – health ministries, multilateral institutions, research institutions, media organisations, technology platforms, and civil society.","plannedDates":[{"endDate":"2029-07-31T00:00:00+00:00","startDate":"2026-08-01T00:00:00+00:00"}],"amountAwarded":305989.2,"Financial Year":"2025/26","Lead Applicant":"Prof Heidi J Larson","grantProgramme":[{"title":"Discretionary Award"}],"Applicant Surname":"Larson","Approval Committee":"Discretionary Award decision meeting","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","addressLocality":"London"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":"305989.2"},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine/","org_id":"360G-Wellcome-ORG:London-School-of-Hygiene-&-Tropical-Medicine"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}}]}