{"count":84,"next":null,"previous":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme/grants_received/?limit=100","results":[{"grant_id":"360G-Wellcome-214622_Z_18_Z","data":{"id":"360G-Wellcome-214622_Z_18_Z","title":"Examining the economic burden, experiences and coping strategies for patients with hypertension in Kenya  ","Region":"International","currency":"GBP","awardDate":"2018-11-21T00:00:00+00:00","Sponsor(s)":"Prof Edwine Barasa","Internal ID":"214622/Z/18/Z","description":"The growing burden of non-communicable diseases (NCDs) has been identified as one of the leading threats to economic growth. Mortality and morbidity due to NCDs result in significant economic impact on households, health systems and societies through draining of household incomes, straining of health system resources, and losses in income, productivity and capital formation. To galvanize support for and inform responses to tackling NCDs, evidence on the economic burden, patient experiences with the health system and coping strategies for these illnesses is needed. In Kenya, this evidence is limited. My proposed study will fill this knowledge gap. I intend to use a mixed- methods approach; employing both quantitative economic methods, and qualitative inquiry through in-depth interviews (IDIs) to examine the economic burden of hypertension to Kenyan households and to assess the experiences and coping strategies for individuals diagnosed with hypertension. To estimate the economic burden of hypertension to households, the study will employ the cost- of-illness approach. To explore the experiences and coping strategies of hypertensive patients, I will collect narratives through in-depth non- structured interviews with participants drawn from different socio-economic quintiles. Evidence from this study will inform health system policy and practice in Kenya and similar settings.","plannedDates":[{"endDate":"2022-07-13T00:00:00+00:00","startDate":"2019-01-14T00:00:00+00:00"}],"amountAwarded":120000,"Financial Year":"2018/19","Lead Applicant":"Mr Robinson Oyando Omondi","grantProgramme":[{"title":"International Masters Fellowship"}],"Applicant Surname":"Omondi","Approval Committee":"International Interview Committee","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme","name":"Kemri-Wellcome Trust Research Programme","addressCountry":"Kenya","addressLocality":"Kilifi"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":120000},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme/","org_id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-214624_Z_18_Z","data":{"id":"360G-Wellcome-214624_Z_18_Z","title":"Examining the implementation of performance based financing for primary healthcare in Kenya  ","Region":"International","currency":"GBP","awardDate":"2018-11-21T00:00:00+00:00","Sponsor(s)":"Prof Edwine Barasa","Internal ID":"214624/Z/18/Z","description":"Performance based financing (PBF) is a type of results based financing that aims to improve the quantity and quality of healthcare services by offering financial incentives to healthcare workers upon achievement of predefined performance measures. Kenya has introduced PBF for peripheral healthcare facilities in 20 (out of 47) counties. This health system reform has the potential to significantly influence how these facilities operate. Beyond design, how a policy reform is introduced and implemented influences the extent to which it achieves its intended goal. Understanding how PBF in Kenya was introduced and implemented, and how this has influenced its effects is therefore an important research and policy question. This study aims to understand how PBF was designed, implemented and stakeholder perceptions of its intended and unintended effects. It will also examine the changes over time for PBF performance indicators. This will be a mixed-methods study. Qualitative data will be collected through in-depth interviews, focus group discussions and document review, while quantitative data on PBF performance indicators will be extracted from district health information system and evaluation reports. Qualitative data will be analyzed by framework analysis while analysis of PBF indicator changes over time will be conducted on the quantitative data.","plannedDates":[{"endDate":"2022-07-13T00:00:00+00:00","startDate":"2019-01-14T00:00:00+00:00"}],"amountAwarded":120000,"Financial Year":"2018/19","Lead Applicant":"Mr Dennis Wambiri Waithaka","grantProgramme":[{"title":"International Masters Fellowship"}],"Applicant Surname":"Waithaka","Approval Committee":"International Interview Committee","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme","name":"Kemri-Wellcome Trust Research Programme","addressCountry":"Kenya","addressLocality":"Kilifi"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":120000},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme/","org_id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-215745_Z_19_Z","data":{"id":"360G-Wellcome-215745_Z_19_Z","title":"Enhancing evidence informed decision making (EEVIDEM) for health in Kenya  ","Region":"International","currency":"GBP","awardDate":"2019-01-21T00:00:00+00:00","Internal ID":"215745/Z/19/Z","description":"While the KEMRI-Wellcome Trust Research Programme (KWTRP) has been doing policy engagement, this has been characterized by fragmented individual researcher and research project specific initiatives. The programme is now keen on institutionalizing and deepening its policy engagement efforts and has allocated resources to support a full time policy engagement position with the responsibility of developing and implementing a programme wide policy engagement strategy. Our proposal aims to complement this commitment by piloting selected policy engagement strategies as part of a systematic and institutionalized policy engagement framework within the KWTRP. Specifically, we will pilot a combination of the following strategies: a) researcher embeddedness within Ministry of Health (MOH) and county department of healths policy making processes b) regular policy dialogue between researchers, policy makers and other health policy stakeholders, and c) reciprocal secondment of staff between the KWTRP and the Kenya MOH. These strategies are aimed at facilitating the bi-directional engagement between KWTRP researchers and health policy makers that will enhance the influence of programme research on health policy decisions, alignment of KWTRP research with health system priorities, and health policy makers demand of research evidence. We will use theory driven evaluation approaches to evaluate the pilot.","plannedDates":[{"endDate":"2021-10-31T00:00:00+00:00","startDate":"2019-05-01T00:00:00+00:00"}],"amountAwarded":74944,"Financial Year":"2018/19","Lead Applicant":"Prof Edwine Barasa","grantProgramme":[{"title":"Policy Engagement Award"}],"Applicant Surname":"Barasa","Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme","name":"Kemri-Wellcome Trust Research Programme","addressCountry":"Kenya","addressLocality":"Kilifi"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":74944},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme/","org_id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-216444_Z_19_Z","data":{"id":"360G-Wellcome-216444_Z_19_Z","title":"Functional studies of the malaria-protective Dantu polymorphism  ","Region":"International","currency":"GBP","awardDate":"2019-06-18T00:00:00+00:00","Sponsor(s)":"Prof Julian Rayner, Prof Thomas Williams","Internal ID":"216444/Z/19/Z","description":"Recent high throughput studies have identified multiple human genetic polymorphisms associated with strong protection against severe and complicated Plasmodium falciparum malaria. Most of these are found in or near genes that are important for the structure and function of red blood cells (RBCs), the primary host cell for P. falciparum parasites in humans. Of particular interest is a novel structural polymorphism in the glycophorin (GYP) locus, a GYPA and GYPB gene rearrangement resulting in a hybrid gene encoding the Dantu blood group. Dantu is found at highest frequency on the East African coast of Kenya. Given the important functional role of the GYP proteins in the invasion of P. falciparum parasites into RBCs, and the strong protective effect of Dantu against severe malaria, developing a full understanding of the protective mechanism might enable the development of new interventions that inhibit invasion. Over the last two years I have established that Dantu impedes parasite invasion by impacting the RBC biophysical properties. I propose to elucidate the molecular mechanisms through which this is achieved, how P. falciparum adapts to the changing RBC environment, and the wider health consequences of Dantu that have driven its selection in East Africa.","plannedDates":[{"endDate":"2026-04-30T00:00:00+00:00","startDate":"2021-01-01T00:00:00+00:00"}],"amountAwarded":269347,"Financial Year":"2018/19","Lead Applicant":"Dr Silvia N Kariuki","grantProgramme":[{"title":"International Training Fellowship"}],"Applicant Surname":"Kariuki","Approval Committee":"International Interview Committee","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme","name":"Kemri-Wellcome Trust Research Programme","addressCountry":"Kenya","addressLocality":"Kilifi"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"Yes","Total amount including partnership funding":269347},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme/","org_id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-218338_Z_19_Z","data":{"id":"360G-Wellcome-218338_Z_19_Z","title":"Improving clinical handovers and communication to improve continuity of care for hospitalized small and sick newborns in selected public hospitals in Kenya.  ","Region":"International","currency":"GBP","awardDate":"2019-07-09T00:00:00+00:00","Sponsor(s)":"Prof Edwine Barasa","Internal ID":"218338/Z/19/Z","description":"Clinical handovers involve transferring patient responsibility and accountability between outgoing and incoming healthcare providers across shifts and disciplines. It has been highlighted as the most vulnerable time in patient care. Communication failures during handovers have been linked to adverse events, jeopardizing patient safety. Many techniques have been used to improve handovers and communication in health care settings in High Income Countries (HICs) often focused on standardizing information transfer. The SBAR (Situation, Background, Assessment and Recommendation) structured handover approach is often regarded as a ‘best practice’ technique in critical care that has led to reductions of medical errors and enhanced safety culture. In LMICs, including Kenya interventions to improve handovers have not been implemented. In this study, focusing on neonatal ward care I propose: i) to systematically review tools used to improve and evaluate effects of handover interventions, ii) explore current Kenyan nurses’ handover practices and develop with them a contextually appropriate tool to improve and standardize handovers and, iii) to conduct a pilot implementation study using mixed methods (focus group discussions and a survey) to assess its potential effectiveness. This fellowship will then provide the preliminary evidence needed to inform the design future funding proposals for larger implementation studies.","plannedDates":[{"endDate":"2022-10-31T00:00:00+00:00","startDate":"2019-09-01T00:00:00+00:00"}],"amountAwarded":60000,"Financial Year":"2018/19","Lead Applicant":"Ms Joyline Jepkosgei","grantProgramme":[{"title":"International Masters Fellowship"}],"Partnership Name":"NIHR/Wellcome Global health Partnership","Applicant Surname":"Jepkosgei","Approval Committee":"International Interview Committee","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme","name":"Kemri-Wellcome Trust Research Programme","addressCountry":"Kenya","addressLocality":"Kilifi"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":120000},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme/","org_id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-218348_Z_19_Z","data":{"id":"360G-Wellcome-218348_Z_19_Z","title":"Examining the implementation of the Kenya Community Health Strategy in urban informal settlements  ","Region":"International","currency":"GBP","awardDate":"2019-07-09T00:00:00+00:00","Sponsor(s)":"Prof Edwine Barasa","Internal ID":"218348/Z/19/Z","description":"The Kenya Community Health Strategy (CHS) is a plan of action to expand community access to health care using - amongst other measures - community health volunteers (CHVs). The CHS has had varying degrees of success with ongoing discussions on how to strengthen it. There is limited information on implementation of the CHS in urban informal settlements (‘slums’) such as those located in Nairobi, Kenya. This is despite such areas accounting for a high burden of disease. Focusing on four large slums within Nairobi County and utilizing a qualitative exploratory approach, this study seeks to understand what influences the performance of CHVs. Individual and group interviews will be conducted with various cadres of health staff at sub-national and community level. These will be supplemented with observations and document reviews. Data will be analysed using framework analysis. The findings from this work will have direct relevance on ongoing policy discussions and strategies on how to strengthen the role of CHVs to attain universal health coverage (UHC). Findings will also inform potential future intervention studies on the effectiveness of CHVs to support the recovery of ill children post hospital admission.","plannedDates":[{"endDate":"2022-11-14T00:00:00+00:00","startDate":"2019-08-15T00:00:00+00:00"}],"amountAwarded":60000,"Financial Year":"2018/19","Lead Applicant":"Mr Michael Otieno Ogutu","grantProgramme":[{"title":"International Masters Fellowship"}],"Partnership Name":"NIHR/Wellcome Global health Partnership","Applicant Surname":"Ogutu","Approval Committee":"International Interview Committee","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme","name":"Kemri-Wellcome Trust Research Programme","addressCountry":"Kenya","addressLocality":"Kilifi"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":120000},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme/","org_id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-218647_Z_19_Z","data":{"id":"360G-Wellcome-218647_Z_19_Z","title":"The CINAMR (Clinical Information Network-Antimicrobial Resistance) Project: A pilot microbial surveillance using hospitals linked to regional laboratories in Kenya  ","Region":"International","currency":"GBP","awardDate":"2019-09-30T00:00:00+00:00","Internal ID":"218647/Z/19/Z","description":"Globally, antimicrobial resistance (AMR) has been identified as a major threat to human health, but effective surveillance in lower and middle-income countries (LMICs) has been difficult to establish. Public facilities lack reliable basic infrastructure for microbiological services and antibiotic use is largely empirical. There are renewed global efforts to establish AMR surveillance and similarly Kenya has developed an action plan for tracking AMR. It is unrealistic to implement microbiology processes based purely on high-income country practice models, and a model appropriate to LMIC settings is required. We propose to demonstrate a hub-and-spoke embedded surveillance programme using the Clinical Information Network (CIN), an already established collaboration between KEMRI-Wellcome Trust Research Programme (KWTRP), the Kenya Paediatric Association (KPA), Kenya’s Ministry of Health and selected County Referral Hospitals in Kenya. Implementation will produce AMR surveillance data from CIN hospitals, but also demonstrate the feasibility of our hub-and-spoke approach for other settings, build capacity for uptake of microbiology data in Kenyan hospitals and describe the impact of these data in clinical practice. CINAMR will also feed into other initiatives such as ACORN network in Southeast Asia, WHO’s Global Antimicrobial Resistance Surveillance System (GLASS), and the Global Research on Antimicrobial Resistance (GRAM) Study","plannedDates":[{"endDate":"2024-03-31T00:00:00+00:00","startDate":"2021-04-01T00:00:00+00:00"}],"amountAwarded":806136,"Financial Year":"2018/19","Lead Applicant":"Dr Samuel Owuor Akech","grantProgramme":[{"title":"Discretionary award - DRI"}],"Applicant Surname":"Akech","Approval Committee":"Internal Decision Panel","Other Applicant(s)":"Prof Jacob McKnight, Prof Michael C English, Prof Paul Turner, Prof Samuel Mungai Kariuki, Prof Philip A. Bejon, Prof Ambrose Agweyu, Dr Nathanial K Copeland, Prof Susanna Jane Dunachie","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme","name":"Kemri-Wellcome Trust Research Programme","addressCountry":"Kenya","addressLocality":"Kilifi"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"Yes","Total amount including partnership funding":806136},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme/","org_id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-221997_Z_20_Z","data":{"id":"360G-Wellcome-221997_Z_20_Z","title":"Enhancing growth and development among malnourished infants recovering from serious illness  ","Region":"International","currency":"GBP","awardDate":"2020-11-24T00:00:00+00:00","Sponsor(s)":"Prof Philip Bejon","Internal ID":"221997/Z/20/Z","description":"Globally, acute malnutrition affects 8.5 million infants under 6 months of age (u6m). Malnourished infants u6m are at elevated risk of death during admission and after discharge from hospital and of subsequent neurodevelopmental impairment. WHO nutritional rehabilitation guidelines for u6m focus on re- establishing exclusive breastfeeding (EBF) with discharge when consistent weight gain (>5g/kg/day) is achieved on breastmilk alone. My pilot study examined breastfeeding peer supporters to facilitate guideline implementation among hospitalised malnourished infants. We achieved 81% exclusive breastfeeding by discharge with 67% attaining the WHO recommended growth velocity on breastmilk alone. However, criteria for full nutritional recovery were generally not met 6 weeks after discharge. I now hypothesise that providing support during transition to home will improve nutritional recovery. In Phase 1 I will develop and pilot a breastfeeding support intervention among 30 recovering infants u6m. In Phase 2 I will apply a randomised controlled trial to evaluate effectiveness of the finalised intervention compared with standard care among 250 malnourished infants (4-12 weeks old) recovering from an illness. The primary outcome is growth (weight gain) assessed at age 6 months, with follow up to 12 months. Results will inform efforts to improve post-discharge management of recovering vulnerable infants u6m.","plannedDates":[{"endDate":"2028-07-31T00:00:00+00:00","startDate":"2022-02-01T00:00:00+00:00"}],"amountAwarded":347486.5,"Financial Year":"2020/21","Lead Applicant":"Dr Martha Kaeni Mwangome","grantProgramme":[{"title":"International Intermediate Fellowship"}],"Partnership Name":"NIHR/Wellcome Global health Partnership","Applicant Surname":"Mwangome","Approval Committee":"International Interview Committee","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme","name":"Kemri-Wellcome Trust Research Programme","addressCountry":"Kenya","addressLocality":"Kilifi"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":694973},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme/","org_id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-221998_Z_20_Z","data":{"id":"360G-Wellcome-221998_Z_20_Z","title":"Investigating the prevalence, clinical consequences and associations of red blood cell alloimmunization among children with sickle cell disease in Kilifi Kenya  ","Region":"International","currency":"GBP","awardDate":"2020-11-24T00:00:00+00:00","Sponsor(s)":"Prof Russell Ware, Prof Philip Bejon","Internal ID":"221998/Z/20/Z","description":"Sickle cell disease (SCD) is the most important genetic disorder in sub- Saharan Africa, where over 280,000 affected children are born every year. Although children with SCD represent only 1-2% of all births within the region, they receive between 10 and 25% of all the blood transfusions administered to children <5 years old. Frequent transfusions put children at risk of erythrocyte alloimmunization - the generation of antibodies to major, minor or variant red blood cell antigens. Blood matching for minor red cell antigens is rarely undertaken in sub-Saharan Africa, and likely increases the risk of alloimmunization. My fellowship has two main aims. First, I will describe the prevalence and consequences of alloimmunization among children attending the SCD clinic at Kilifi County Hospital in Kenya. Second, I will explore potential risk factors for the development of alloimmunization, including levels of inflammation within transfusion recipients and red blood cell genetic diversity in both donors and recipients. By identifying risk factors that contribute to alloimmunization, I will contribute to the development of better strategies that reduce the chance of development of alloimmunization for the transfusion management of patients with SCD in Africa.","plannedDates":[{"endDate":"2027-08-31T00:00:00+00:00","startDate":"2021-09-01T00:00:00+00:00"}],"amountAwarded":574957,"Financial Year":"2020/21","Lead Applicant":"Dr Sophie Uyoga","grantProgramme":[{"title":"International Intermediate Fellowship"}],"Applicant Surname":"Uyoga","Approval Committee":"International Interview Committee","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme","name":"Kemri-Wellcome Trust Research Programme","addressCountry":"Kenya","addressLocality":"Kilifi"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"Yes","Total amount including partnership funding":574957},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme/","org_id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-222125_Z_20_Z","data":{"id":"360G-Wellcome-222125_Z_20_Z","title":"Enteric Pathogens and Post-discharge Outcomes among Children in sub-Saharan Africa and South Asia (The EPPO-SASA Study)  ","Region":"International","currency":"GBP","awardDate":"2020-11-24T00:00:00+00:00","Sponsor(s)":"Prof Samson Kinyanjui","Internal ID":"222125/Z/20/Z","description":"Enteric pathogens are a major cause of hospitalisation among children and are associated with diarrhoea, enteric dysfunction, dysbiosis, and increased risk of mortality and readmission especially in low- and middle-income countries. When admitted to hospital, treatment failure may occur despite following guidelines. Furthermore, carriage of pathogens or disturbance in the intestinal microbiome may be hospital-acquired and/or resistant to first-line antimicrobials potentially increasing the risk of readmission. I aim to determine whether molecular evidence of enteric pathogens and gut dysbiosis at hospital discharge, when children were judged as clinically well, is associated with readmission post-discharge among children across the nutritional stratum. This case-control study is nested within the completed CHAIN cohort study (six countries) that aims to characterise demographic, clinical, and social risk factors for mortality among children <2 years old, with an extensive nested case-cohort systems biology sub-study targeting mortality. Cases will be children readmitted to hospital within 6 months of index discharge and controls will be age, nutritional stratum and site matched children who were not readmitted. I will utilise targeted faecal TaqMan multiplex PCR (Kilifi, Kenya), culturomics and metagenomics (Sanger Institute, UK). Findings may support policies for post-discharge screening, prophylaxis, targeted diagnostics, and revision of treatment protocols.","plannedDates":[{"endDate":"2024-02-01T00:00:00+00:00","startDate":"2021-08-02T00:00:00+00:00"}],"amountAwarded":97200,"Financial Year":"2020/21","Lead Applicant":"Mr Bonface Mutitu Gichuki","grantProgramme":[{"title":"International Masters Fellowship"}],"Applicant Surname":"Gichuki","Approval Committee":"International Interview Committee","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme","name":"Kemri-Wellcome Trust Research Programme","addressCountry":"Kenya","addressLocality":"Kilifi"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"Yes","Total amount including partnership funding":97200},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme/","org_id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-222967_B_21_Z","data":{"id":"360G-Wellcome-222967_B_21_Z","title":"Systemic Inflammation and Growth following Acute Illness in Children.  ","Region":"International","currency":"GBP","awardDate":"2021-06-23T00:00:00+00:00","Sponsor(s)":"Prof Philip Bejon, Dr Trevor Lawley, Prof Holm Uhlig","Internal ID":"222967/B/21/Z","description":"Medical and nutritional management in acutely-ill undernourished children in developing countries aim to support rapid weight gain. However, such children remain at risk of death and poor catch-up growth post-hospital discharge. Little is known about mechanisms regulating childhood growth after acute illness. I hypothesise that persistent systemic inflammation (SI) is a key determinant of growth post-discharge among undernourished children. SI is associated with reduced linear growth in community cohorts, and is demonstrable at hospital discharge among undernourished children, potentially indicating untreated infections, microbiota dysbiosis, gut-circulation microbial product translocation, or enteric inflammation. My proposed work is nested within the CHAIN cohort that aims to characterise modifiable risks for mortality among acutely-ill children <2 years old in six countries in Africa and Asia. I aim to investigate whether persistent SI is a key determinant of catch-up growth among undernourished children and investigate its causes. I will examine relationships between growth and markers of SI, blood metabolomic profile, growth mediators, and microbial exposures comparing with well community children through a collaborative network between KEMRI-Wellcome; Kenya, the University of Oxford and the Wellcome Sanger Institute. Better understanding of relationships between SI and post-discharge growth is expected to inform therapeutic strategies to improve recovery.","plannedDates":[{"endDate":"2026-09-30T00:00:00+00:00","startDate":"2021-10-01T00:00:00+00:00"}],"amountAwarded":244713.93,"Financial Year":"2020/21","Lead Applicant":"Dr James Mwangi Njunge","grantProgramme":[{"title":"International Intermediate Fellowship"}],"Partnership Name":"NIHR/Wellcome Global health Partnership","Applicant Surname":"Njunge","Approval Committee":"International Interview Committee","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme","name":"Kemri-Wellcome Trust Research Programme","addressCountry":"Kenya","addressLocality":"Kilifi"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"Yes","Total amount including partnership funding":"489427.85"},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme/","org_id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-222967_Z_21_Z","data":{"id":"360G-Wellcome-222967_Z_21_Z","title":"Systemic Inflammation and Growth following Acute Illness in Children.  ","Region":"International","currency":"GBP","awardDate":"2021-06-23T00:00:00+00:00","Sponsor(s)":"Prof Holm Uhlig, Prof Philip Bejon, Dr Trevor Lawley","Internal ID":"222967/Z/21/Z","description":"Medical and nutritional management in acutely-ill undernourished children in developing countries aim to support rapid weight gain. However, such children remain at risk of death and poor catch-up growth post-hospital discharge. Little is known about mechanisms regulating childhood growth after acute illness. I hypothesise that persistent systemic inflammation (SI) is a key determinant of growth post-discharge among undernourished children. SI is associated with reduced linear growth in community cohorts, and is demonstrable at hospital discharge among undernourished children, potentially indicating untreated infections, microbiota dysbiosis, gut-circulation microbial product translocation, or enteric inflammation. My proposed work is nested within the CHAIN cohort that aims to characterise modifiable risks for mortality among acutely-ill children <2 years old in six countries in Africa and Asia. I aim to investigate whether persistent SI is a key determinant of catch-up growth among undernourished children and investigate its causes. I will examine relationships between growth and markers of SI, blood metabolomic profile, growth mediators, and microbial exposures comparing with well community children through a collaborative network between KEMRI-Wellcome; Kenya, the University of Oxford and the Wellcome Sanger Institute. Better understanding of relationships between SI and post-discharge growth is expected to inform therapeutic strategies to improve recovery.","plannedDates":[{"endDate":"2026-09-30T00:00:00+00:00","startDate":"2021-10-01T00:00:00+00:00"}],"amountAwarded":122496,"Financial Year":"2020/21","Lead Applicant":"Dr James Mwangi Njunge","grantProgramme":[{"title":"International Intermediate Fellowship"}],"Partnership Name":"NIHR/Wellcome Global health Partnership","Applicant Surname":"Njunge","Approval Committee":"International Interview Committee","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme","name":"Kemri-Wellcome Trust Research Programme","addressCountry":"Kenya","addressLocality":"Kilifi"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"Yes","Total amount including partnership funding":298992},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme/","org_id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-223658_Z_21_Z","data":{"id":"360G-Wellcome-223658_Z_21_Z","title":"Identifying Community Pharmacists Preferences for Attributes of Public Health Interventions Delivered Through Private Retail Pharmacies: A Discrete Choice Experiment  ","Region":"International","currency":"GBP","awardDate":"2021-06-23T00:00:00+00:00","Sponsor(s)":"Prof Samson Kinyanjui","Internal ID":"223658/Z/21/Z","description":"Private retail pharmacies are the first point of contact for most people seeking treatment for minor illness in LMICs. They play a significant role in delivery of public health interventions (PHIs). In Kenya, for example, retail pharmacies are involved in the provision of family planning services, HIV counselling and testing services and malaria treatment. Despite the role private retail pharmacies play in delivering PHIs, there is limited evidence on the attributes of PHIs that community pharmacists (pharmacists working in private retail pharmacies) value and the trade-offs they would be willing to make. Moreover, private retail pharmacies have competing interests aimed at maximizing profits. It is therefore essential that the contracts policy makers design for them are aligned with their incentives. The proposed study aims to elicit the preferences of community pharmacists for attributes of PHIs in Kenya, utilizing a discrete the choice experiment (DCE) approach. A DCE is a stated preference method used to elicit individuals’ preferences for goods and services using hypothetical scenarios. The mixed-method study will involve 350 participants from 4 counties. Data will be analyzed using thematic analysis and conditional-logit model. Findings will inform policy makers in design and implementation of PHIs through private retail pharmacies.","plannedDates":[{"endDate":"2024-10-03T00:00:00+00:00","startDate":"2021-08-04T00:00:00+00:00"}],"amountAwarded":60000,"Financial Year":"2020/21","Lead Applicant":"Ms Audrey Mumbi","grantProgramme":[{"title":"International Masters Fellowship"}],"Partnership Name":"NIHR/Wellcome Global health Partnership","Applicant Surname":"Mumbi","Approval Committee":"International Interview Committee","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme","name":"Kemri-Wellcome Trust Research Programme","addressCountry":"Kenya","addressLocality":"Kilifi"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"Yes","Total amount including partnership funding":120000},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme/","org_id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-224272_Z_21_Z","data":{"id":"360G-Wellcome-224272_Z_21_Z","title":"Registering Births and Deaths in Kenya: Current problems, solution pathways and interventions.  ","Region":"International","currency":"GBP","awardDate":"2021-11-30T00:00:00+00:00","Internal ID":"224272/Z/21/Z","description":"The lack of reliable, timely data on deaths (who, when, what) and births in SSA continues to pose a considerable challenge to estimating intervention needs. Many events across Africa remain invisible to national and international health metrics and health system planners. Informed health policy requires reliable descriptions of births and the age, sex and causes of death for the entire population. New context-specific evidence is required to understand the challenges that plague CRVS systems in Africa. I will use a network of surveillance sites in Kenya to answer four related questions: a) What and where are the gaps and inefficiencies in the current civil registration processes? b) What is the true proportion of unregistered births and deaths in Kenya? c) do individuals have the same probability of being registered by CRVS when they are born or when they die? and d) Why are some births or deaths not registered and are these events systematically different, and what are the potential opportunities and strategies to strengthen registration of all children. This body of work will inform the design of an intervention package aimed at improved monitoring of changes in mortality and natality and demonstrate how to achieve comprehensive CRVS in Kenya","plannedDates":[{"endDate":"2028-06-30T00:00:00+00:00","startDate":"2022-05-01T00:00:00+00:00"}],"amountAwarded":1749268.07,"Financial Year":"2021/22","Lead Applicant":"Prof Emelda Aluoch Okiro","grantProgramme":[{"title":"Senior Research Fellowship"}],"Applicant Surname":"Okiro","Approval Committee":"Science Interview Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme","name":"Kemri-Wellcome Trust Research Programme","addressCountry":"Kenya","addressLocality":"Kilifi"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"Yes","Total amount including partnership funding":"1749268.07"},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme/","org_id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-224315_Z_21_Z","data":{"id":"360G-Wellcome-224315_Z_21_Z","title":"Investigating the mechanisms underlying the relationship between severe anaemia and bacterial infections  ","Region":"International","currency":"GBP","awardDate":"2021-11-18T00:00:00+00:00","Sponsor(s)":"Prof Anthony Scott","Internal ID":"224315/Z/21/Z","description":"Severe anaemia and bacteraemia are strongly associated in African children, although the precise mechanisms underlying this association remain unknown. I found that this association is observed with specific organisms (e.g. Escherichia.coli, non-typhoidal Salmonella) but not others (e.g. Staphylococcus aureus). Given the multiple putative aetiologies of severe anaemia and increase in antimicrobial resistance, developing a full understanding of the mechanisms that predispose to these bacterial infections will enable the development of better interventions. I propose to test the hypothesis that disruption of iron metabolism and/or immune pathways contributes to increased risk of bacterial infections among severely anaemic children. I will utilise clinical and laboratory data and samples collected over the last 21 years to examine the associations between severe anaemia, immune responses, bacterial iron acquisition and genetic signatures of bacteria during severe anaemia. I will also evaluate the effects of anaemia on bacterial vaccine responses using data and samples from vaccine trials conducted in Kilifi. Findings from this project will elucidate key iron and immune pathways that can be targeted to develop interventions for severe anaemia and prevention of bacteraemia.","plannedDates":[{"endDate":"2026-03-31T00:00:00+00:00","startDate":"2022-04-01T00:00:00+00:00"}],"amountAwarded":123536.5,"Financial Year":"2021/22","Lead Applicant":"Kelvin Mokaya Abuga","grantProgramme":[{"title":"International Training Fellowship"}],"Partnership Name":"NIHR/Wellcome Global health Partnership","Applicant Surname":"Abuga","Approval Committee":"International Interview Committee","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme","name":"Kemri-Wellcome Trust Research Programme","addressCountry":"Kenya","addressLocality":"Kilifi"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"Yes","Total amount including partnership funding":247073},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme/","org_id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-224317_Z_21_Z","data":{"id":"360G-Wellcome-224317_Z_21_Z","title":"Using Mendelian randomisation to determine whether iron status is causally linked to severe infections and death in African children  ","Region":"International","currency":"GBP","awardDate":"2021-11-18T00:00:00+00:00","Sponsor(s)":"Prof Thomas Williams","Internal ID":"224317/Z/21/Z","description":"Despite high prevalence of iron deficiency and anaemia in Africa, there are longstanding concerns regarding whether treatment of iron deficiency by giving iron supplements increases the risk of infections, hospitalisation, and deaths. Previous studies have not conclusively addressed this dilemma due to study design limitations such as confounding bias, reverse causality and a requirement of large sample sizes and long follow-up times to investigate rare outcomes in clinical trials. During my post-doctoral studies, I conducted a GWAS and identified novel genetic variants that are unique to African populations that can be used to proxy iron status and anaemia. This now affords me the unique and exciting opportunity to test how these variants influence severe infections and mortality using a Mendelian randomisation approach that overcomes many of the limitations of previous study designs. I propose to identify likely causal genetic variants through fine-mapping, comprehensive functional annotation, and integration of my findings with transcriptomic and epigenomic data. I will then determine whether the prioritised causal variants influence risk of severe malaria, bacteraemia, tuberculosis, and mortality using already available data/samples from large case-control studies in Africa. This novel approach has not previously been applied to iron status and infections/deaths in Africa.","plannedDates":[{"endDate":"2026-03-31T00:00:00+00:00","startDate":"2022-04-01T00:00:00+00:00"}],"amountAwarded":300867,"Financial Year":"2021/22","Lead Applicant":"Dr John Muthii Muriuki","grantProgramme":[{"title":"International Training Fellowship"}],"Applicant Surname":"Muriuki","Approval Committee":"International Interview Committee","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme","name":"Kemri-Wellcome Trust Research Programme","addressCountry":"Kenya","addressLocality":"Kilifi"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"Yes","Total amount including partnership funding":300867},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme/","org_id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-226002_Z_22_Z","data":{"id":"360G-Wellcome-226002_Z_22_Z","title":"Rates, determinants, and transmissibility of respiratory virus re-infections  ","Region":"International","currency":"GBP","awardDate":"2022-08-31T00:00:00+00:00","Sponsor(s)":"Prof Philip Bejon","Internal ID":"226002/Z/22/Z","description":"Multiple reinfections are characteristic of many respiratory viruses and a critical determinant of endemicity in human populations. However, there is a paucity of data on the rates and determinants of reinfections, and the importance of reinfections in chains of transmission. This project will investigate reinfection for three common respiratory viruses - SARS-CoV-2, influenza, and respiratory syncytial virus - within the household setting. I will determine the frequency and timing of reinfections independent of clinical presentation; identify viral genomic and host immunological characteristics of reinfections; and determine the factors that influence the transmission potential of reinfections. My proposal includes a three-year household cohort study in coastal Kenya, with intensive respiratory sampling for RT-PCR and genomic sequencing, and bimonthly blood samples to assess immune status and serological responses relating to reinfection. I will estimate the rate of immunity loss and reinfection infectiousness in relation to age, virus load, symptoms, and host immunity, and use mathematical models to explore the transmission dynamics and intervention impact building on the new understanding from this research.","plannedDates":[{"endDate":"2031-01-31T00:00:00+00:00","startDate":"2023-02-01T00:00:00+00:00"}],"amountAwarded":2151866.33,"Financial Year":"2021/22","Lead Applicant":"Dr Charles Nyaigoti Agoti","grantProgramme":[{"title":"Career Development Award"}],"Applicant Surname":"Agoti","Approval Committee":"CDA Interview Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme","name":"Kemri-Wellcome Trust Research Programme","addressCountry":"Kenya","addressLocality":"Kilifi"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"Yes","Total amount including partnership funding":"2151866.33"},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme/","org_id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-226130_Z_22_Z","data":{"id":"360G-Wellcome-226130_Z_22_Z","title":"Platform for rapid immunological characterization of SARS CoV-2 variants in Kenya and the Eastern Africa Region  ","Region":"International","currency":"GBP","awardDate":"2022-07-05T00:00:00+00:00","Internal ID":"226130/Z/22/Z","description":"We propose to augment our well-established genomics surveillance infrastructure with a well-structured and coordinated platform for continuous immunological surveillance and characterization of emerging SARS-CoV-2 variants within Kenya and the Eastern Africa region. We will assemble a network of collaborating health facilities across Kenya and the Eastern Africa region to contribute genomic and immunology samples. Our current status as an Africa CDC/WHO-AFRO regional genomic reference laboratory has facilitated bidirectional sample and data sharing with Ministry of Health teams from Eastern Africa and will be a key feature of the immunology work. We will determine whether newly emergent variants exhibit substantial changes in their sensitivity to neutralization by antibodies induced by vaccination and natural infection, and consequently predict the likely impact on vaccine effectiveness. In addition, we will establish a monoclonal antibody discovery pipeline to rapidly identify variant specific or cross-neutralizing monoclonal antibodies. The network will therefore produce directly actionable health intelligence to support local and international public health policy adjustments to curtail the negative health and economic impacts of the virus.","plannedDates":[{"endDate":"2027-01-02T00:00:00+00:00","startDate":"2023-01-03T00:00:00+00:00"}],"amountAwarded":2268260,"Financial Year":"2021/22","Lead Applicant":"Prof Lynette Isabella Oyier","grantProgramme":[{"title":"Directed Call"}],"Applicant Surname":"Oyier","Approval Committee":"Epidemic Technical Advisory Panel","Other Applicant(s)":"Dr Charles J Sande, Prof Ambrose Agweyu, Dr George Githinji, Dr Eunice Wambui Nduati, Dr James Jimmy Nyagwange, Dr Peter Kimutai Borus, Prof Philip A. Bejon","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme","name":"Kemri-Wellcome Trust Research Programme","addressCountry":"Kenya","addressLocality":"Kilifi"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"Yes","Total amount including partnership funding":2268260},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme/","org_id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-227329_Z_23_Z","data":{"id":"360G-Wellcome-227329_Z_23_Z","title":"Impacts of Health Systems Governance on Antimicrobial Resistance Containment in Kenya and Vietnam  ","Region":"International","currency":"GBP","awardDate":"2023-05-16T00:00:00+00:00","Sponsor(s)":"Prof Edwine Barasa","Internal ID":"227329/Z/23/Z","description":"Governance is a critical determinant in the performance of health systems. However, it is still a relatively under-researched concept in health systems. Specifically, limited studies have been conducted on the role of governance in antimicrobial resistance (AMR) containment especially in low- and middle- income countries (LMICs). Through this research, I will lead a team to understand how health systems governance structures, functions and processes affect AMR containment using Kenya and Vietnam as LMIC case studies. Kenya has a decentralized health system while Vietnam has a centralized one. Although Kenya and Vietnam have national action plans (NAPs) for 2017-2022 and 2013-2020 cycles respectively, which define governance structures, functions and processes for AMR containment, implementation is not optimal. Guided by decentred governance theory, we will investigate AMR governance challenges from a One Health Approach combining literature review, non-participant observations, and interviews with national and subnational officers working in human and livestock health, agriculture, and environment sectors. Globally, we will assess governance structures adopted by World Health Organization (WHO) member states as outlined in the available 131 NAPs and compare performance in relation to the Global Antimicrobial Resistance Surveillance System (GLASS). Overall, we will make a methodological contribution and inform post 2022 NAPs implementation.","plannedDates":[{"endDate":"2027-01-31T00:00:00+00:00","startDate":"2024-02-01T00:00:00+00:00"}],"amountAwarded":675895,"Financial Year":"2022/23","Lead Applicant":"Dr Edna Mutua","grantProgramme":[{"title":"Career Development Award"}],"Applicant Surname":"Mutua","Approval Committee":"CDA Interview Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme","name":"Kemri-Wellcome Trust Research Programme","addressCountry":"Kenya","addressLocality":"Kilifi"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"Yes","Total amount including partnership funding":675895},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme/","org_id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-227562_Z_23_Z","data":{"id":"360G-Wellcome-227562_Z_23_Z","title":"Building Reliable Information from Data Generated in Everyday practice – the Data BRIDGE project  ","Region":"International","currency":"GBP","awardDate":"2023-07-31T00:00:00+00:00","Sponsor(s)":"Prof Edwine Barasa","Internal ID":"227562/Z/23/Z","description":"Electronic Health Record systems (EHRs) have the potential to improve health data collection and decision-making in sub-Saharan Africa (SSA) for monitoring health system performance, routine maternal, perinatal, and neonatal death surveillance and response (MPNDSR) and for integrated disease surveillance response (IDSR). However, existing EHRs audits reveal that they are challenging and expensive to sustainably implement in SSA. Therefore, in the short-to-medium term, paper-to-digital systems will continue to dominate. This study proposes to improve the quality, volume, and range of data collected through paper-to-digital systems in SSA while reducing the workload of information officers and improving data use culture. This will be achieved by (1) exploring the use of Artificial Intelligence and Machine Learning to develop an efficient, user-friendly clinical informatics pipeline that leverages paper-to-digital systems and (2) identifying how actionable patient- level data from the pipeline can be used for multiple surveillance needs (MPNDSR/IDSR) through optimising Audit and Feedback cycle and mechanisms targeting feedback, recipient and context variables. The initial focus will be on poorly performing neonatal conditions/outcomes exacerbated by global warming. This study aims to bridge the gap between data and information by developing a practical and sustainable solution for improving health data collection and use for decision-making in SSA.","plannedDates":[{"endDate":"2027-12-31T00:00:00+00:00","startDate":"2023-12-01T00:00:00+00:00"}],"amountAwarded":527381,"Financial Year":"2022/23","Lead Applicant":"Dr Timothy Tuti Nganga","grantProgramme":[{"title":"Early-Career Award"}],"Applicant Surname":"Nganga","Approval Committee":"ECA Interview Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme","name":"Kemri-Wellcome Trust Research Programme","addressCountry":"Kenya","addressLocality":"Kilifi"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":527381},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme/","org_id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-228187_Z_23_Z","data":{"id":"360G-Wellcome-228187_Z_23_Z","title":"Enhancing the Use of Economic Evidence in Vaccine Policy-Making in Africa  ","Region":"International","currency":"GBP","awardDate":"2023-09-30T00:00:00+00:00","Internal ID":"228187/Z/23/Z","description":"This project’s ambition is to enhance the use of economic evidence in vaccine policy-making in Africa. Low and middle-income countries face the twin health financing problem of overall resource scarcity and declining donor support. This is especially evident in the funding for vaccines, where donor funding plays a key role, and the main donor (Gavi, the Global Alliance) is implementing a transition plan, progressively shifting funding responsibility to countries. A key strategy to respond to this challenge is the use of explicit, evidence-informed vaccine decision-making processes that incorporate economic evidence on the value for money of alternative options, so as to optimize the value and impact of country vaccine programs within the resources available. This project will 1) support the use of economic methods in vaccine decision-making by developing quality-adjusted life year (QALY) value sets that will improve the validity of cost-effectiveness analysis 2) model the cost-effectiveness of priority vaccines in Kenya, Zambia, and Nigeria, and 3) engage policymakers in these three countries to use economic evidence to optimize the impact and value for money of their vaccination programs.","plannedDates":[{"endDate":"2027-01-01T00:00:00+00:00","startDate":"2024-01-02T00:00:00+00:00"}],"amountAwarded":2173412,"Financial Year":"2022/23","Lead Applicant":"Prof Edwine Barasa","grantProgramme":[{"title":"Discretionary Award"}],"Applicant Surname":"Barasa","Approval Committee":"Internal Decision Panel","Other Applicant(s)":"Prof George Mbugua Warimwe, Prof Dr Felix Masiye, Prof Obinna Emmanuel Onwujekwe, Dr C Nafula Nafula, Dr Stacey Kwamboka Orangi","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme","name":"Kemri-Wellcome Trust Research Programme","addressCountry":"Kenya","addressLocality":"Kilifi"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"Yes","Total amount including partnership funding":2173412},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme/","org_id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-300037_Z_23_Z","data":{"id":"360G-Wellcome-300037_Z_23_Z","title":"Mathematical modelling to improve the efficiency of vaccine development pipelines.  ","Region":"International","currency":"GBP","awardDate":"2023-10-19T00:00:00+00:00","Sponsor(s)":"Prof Philip Bejon","Internal ID":"300037/Z/23/Z","description":"Vaccines are one of the major successes of public health, with modern laboratory techniques allowing the development of vaccines against a wide range of pathogens and speeding their development. Clinical trials (phases III and IV) are often costly and time consuming, acting as a bottleneck to the rapid deployment of vaccines. My project will consider how epidemiological models can be used to enhance the vaccine development pipeline, using five infections as motivating and well-understood case studies: SARS-CoV-2, respiratory syncytial virus, Rift Valley fever, Lassa fever and yellow fever. In this project I will develop a suite of sophisticated models, based on the known epidemiology of the infections and using early immunological data as strong priors on vaccine behaviour. These models will feed into pre-trial quantification of the infection dynamics, assessment of effective and efficient phase III trial design, and evaluation of the impact of deployment within the population. This will be supported by researchers working in vaccine trials and deployment within Kenya and across Africa.","plannedDates":[{"endDate":"2029-07-31T00:00:00+00:00","startDate":"2024-08-01T00:00:00+00:00"}],"amountAwarded":482162,"Financial Year":"2023/24","Lead Applicant":"Dr Ivy KADZO Kombe","grantProgramme":[{"title":"Early-Career Award"}],"Applicant Surname":"Kombe","Approval Committee":"ECA Interview Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme","name":"Kemri-Wellcome Trust Research Programme","addressCountry":"Kenya","addressLocality":"Kilifi"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"Yes","Total amount including partnership funding":482162},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme/","org_id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-306912_Z_23_Z","data":{"id":"360G-Wellcome-306912_Z_23_Z","title":"Extending Trials of fractional doses of yellow fever vaccine for policy impact  ","Region":"International","currency":"GBP","awardDate":"2024-03-31T00:00:00+00:00","Internal ID":"306912/Z/23/Z","description":"Yellow fever (YF) is a zoonotic mosquito-borne viral disease endemic in Africa and South America. Over 100,000 YF cases are estimated to occur annually in Africa which, with a case fatality of 20-50%, represents a major risk to public health. A single dose of licensed YF vaccines provides life-long immunity. However, the vaccine manufacture process is laborious and difficult to scale up rapidly, leading to persistent challenges with global vaccine availability. Fractional dosing with YF vaccines has been adopted by the World Health Organization (WHO) as a strategy to control YF outbreaks, but the durability of the protective immune response following fractional dosing remains unknown. We will address this question by measuring YF neutralizing antibody levels in adults and children who participated in randomized controlled trials of fractional versus standard doses of YF vaccine in Kenya, Uganda and The Gambia. A single cross-sectional sampling of these populations will provide immunogenicity data at 2 to 6 years since the initial vaccination with either fractional or standard vaccine dose. The data from this study will inform WHO recommendations on the use of fractional doses of YF vaccines, including informing decisions on whether a booster dose is needed to maintain long-term protection.","plannedDates":[{"endDate":"2027-10-31T00:00:00+00:00","startDate":"2024-11-01T00:00:00+00:00"}],"amountAwarded":1325943.5,"Financial Year":"2023/24","Lead Applicant":"Prof George Warimwe","grantProgramme":[{"title":"Discretionary Award"}],"Applicant Surname":"Warimwe","Approval Committee":"Discretionary Award decision meeting","Other Applicant(s)":"Dr Valerie Briand, Prof Ed Clarke","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme","name":"Kemri-Wellcome Trust Research Programme","addressCountry":"Kenya","addressLocality":"Kilifi"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":"1325943.5"},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme/","org_id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-315698_Z_24_Z","data":{"id":"360G-Wellcome-315698_Z_24_Z","title":"Rethinking neonatal post-discharge care: Learning from family and healthcare workers experiences of preterm care in Kenya.  ","Region":"International","currency":"GBP","awardDate":"2025-01-14T00:00:00+00:00","Sponsor(s)":"Prof Edwine Barasa","Internal ID":"315698/Z/24/Z","description":"Preterm births are a widely recognised global health concern, and continuity of care for preterm newborns is crucial. A growing number of studies have explored caregiver experiences of in-hospital care of preterm babies in high- income settings, but few have focused on low- and middle-income countries. Fewer still have examined families' lived experiences after discharge from hospital. This is an important research gap. Advancements in medical technologies have improved survival rates for preterm babies, but pre-term babies still face layered biomedical and social vulnerabilities with the potential for long-term development challenges, necessitating repeated follow- up and enhanced family support. In this fellowship, I will build on my in- depth, embedded ethnographic hospital-based work with families of pre-term babies in Kenya to focus on families’ experiences post-discharge, incorporating health workers’ perspectives. Using a qualitative and participatory approach, I will apply transitions theory to explore the stresses and challenges faced by families and healthcare workers, and their vulnerabilities, agency, and coping. Regional studies and my past research suggest that key concerns will be gaps in continuity of care, and family (and especially mother) stigma and social exclusion. Understanding these experiences of care is crucial in the re-design of a holistic, comprehensive people-centred post-discharge care system.","plannedDates":[{"endDate":"2030-12-31T00:00:00+00:00","startDate":"2026-01-01T00:00:00+00:00"}],"amountAwarded":937965,"Financial Year":"2024/25","Lead Applicant":"Dr Dorothy Awuor Oluoch","grantProgramme":[{"title":"Career Development Award"}],"Applicant Surname":"Oluoch","Approval Committee":"CDA Interview Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme","name":"Kemri-Wellcome Trust Research Programme","addressCountry":"Kenya","addressLocality":"Kilifi"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":937965},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme/","org_id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}},{"grant_id":"360G-Wellcome-346698_Z_26_Z","data":{"id":"360G-Wellcome-346698_Z_26_Z","title":"Building an Integrated FAIR-Compliant Data Catalogue and Decision-Support Platform to Maximise Research and Public Health Impact  ","Region":"International","currency":"GBP","awardDate":"2026-06-02T00:00:00+00:00","Internal ID":"346698/Z/26/Z","description":"Despite generating large volumes of valuable research data, many research institutions in low- and middle-income countries (LMICs) struggle to make these datasets discoverable, interoperable, and usable for policy and public health decision-making. Data generated through surveillance systems, clinical trials, laboratory platforms, and implementation research are often fragmented, inconsistently described, and poorly connected to routine health information systems, limiting their scientific and policy value. A key reason for this gap is the lack of institutional infrastructure needed to organise, discover, and integrate research data. Many institutions lack structured metadata standards, data catalogues, and interoperable systems that enable datasets to be easily identified, accessed, and securely linked. As a result, FAIR data principles remain difficult to implement in practice. This project will establish a foundational institutional data ecosystem at the KEMRI–Wellcome Trust Research Programme (KWTRP). It will develop a standards- based data catalogue, implement a data warehouse linking research, surveillance, and contextual datasets such as climate and geospatial data, and create decision-support dashboards translating integrated data into practical insights for researchers and health system stakeholders. The project will also generate practical lessons and reusable frameworks to support responsible data discovery, integration, and use across research institutions and health systems.","plannedDates":[{"endDate":"2027-08-01T00:00:00+00:00","startDate":"2026-08-01T00:00:00+00:00"}],"amountAwarded":199899,"Financial Year":"2025/26","Lead Applicant":"Ms Lillian Elizabeth Chizi Mwango","grantProgramme":[{"title":"Discretionary Award"}],"Applicant Surname":"Mwango","Approval Committee":"Discretionary Award decision meeting","Other Applicant(s)":"Marianne B Munene, Prof Emelda Aluoch Okiro, Dr Anthony Oliwa Etyang, Mr Moses Musau Mutinda, Mr James Bukosia Wafula, Dr Moses Chapa Kiti, Mr Narshion Matai Ngao, Prof Edwine Barasa","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme","name":"Kemri-Wellcome Trust Research Programme","addressCountry":"Kenya","addressLocality":"Kilifi"}],"Has the grant transferred?":"No","Research conducted at multiple locations?":"No","Total amount including partnership funding":199899},"data_license":{"url":"https://creativecommons.org/licenses/by/4.0/","name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"},"publisher":{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"},"recipients":[{"self":"https://api.threesixtygiving.org/api/v1/org/360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme/","org_id":"360G-Wellcome-ORG:Kemri-Wellcome-Trust-Research-Programme"}],"funders":[{"self":"https://api.threesixtygiving.org/api/v1/org/GB-CHC-210183/","org_id":"GB-CHC-210183"}],"additional_data_metadata":{"source_license":"https://creativecommons.org/licenses/by/4.0/","sources_metadata":{"codeListLookup":{"license":"https://creativecommons.org/licenses/by/4.0/"},"locationLookup":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrgInfos":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"},"recipientOrganizationLocation":{"license":"https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/"}},"source_license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)"}}]}